ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1997
A developmental gene (Tolloid/BMP-1) is regulated in Aplysia neurons by treatments that induce long-term sensitization.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
31 citing papers in PubMed, 86 citations in OpenAlex.
- Pattern detection in the TGFβ cascade controls the induction of long-term synaptic plasticity.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Dynamics and Mechanisms of ERK Activation after Different Protocols that Induce Long-Term Synaptic Facilitation inOxford open neuroscience · 2023Article
- Structural and evolutionary insights into astacin metallopeptidases.Frontiers in molecular biosciences · 2022Article
- Article
- Quantitative description of the interactions among kinase cascades underlying long-term plasticity of Aplysia sensory neurons.Scientific reports · 2021Article
- The ELAV family of RNA-binding proteins in synaptic plasticity and long-term memory.Neurobiology of learning and memory · 2019Review
- Functional and structural studies of tolloid-like 1 mutants associated with atrial-septal defect 6.Bioscience reports · 2019Article
- Transcriptional correlates of memory maintenance following long-term sensitization ofLearning & memory (Cold Spring Harbor, N.Y.) · 2017Article
- TGF-β Family Signaling in Neural and Neuronal Differentiation, Development, and Function.Cold Spring Harbor perspectives in biology · 2017Review
- Multifaceted Roles of Metzincins in CNS Physiology and Pathology: From Synaptic Plasticity and Cognition to Neurodegenerative Disorders.Frontiers in cellular neuroscience · 2017Review
- Transforming growth factor β recruits persistent MAPK signaling to regulate long-term memory consolidation in Aplysia californica.Learning & memory (Cold Spring Harbor, N.Y.) · 2016Article
- A Novel, Noncanonical BMP Pathway Modulates Synapse Maturation at the Drosophila Neuromuscular Junction.PLoS genetics · 2016Article
- Article
- Nonassociative learning in invertebrates.Cold Spring Harbor perspectives in biology · 2015Review
- Characterization of the rapid transcriptional response to long-term sensitization training in Aplysia californica.Neurobiology of learning and memory · 2014Article
- Immediate and persistent transcriptional correlates of long-term sensitization training at different CNS loci in Aplysia californica.PloS one · 2014Article
- Inactivity-induced phrenic and hypoglossal motor facilitation are differentially expressed following intermittent vs. sustained neural apnea.Journal of applied physiology (Bethesda, Md. : 1985) · 2013Article
- Gene expression changes of interconnected spared cortical neurons 7 days after ischemic infarct of the primary motor cortex in the rat.Molecular and cellular biochemistry · 2012Article
- Metalloproteinases in Drosophila to humans that are central players in developmental processes.The Journal of biological chemistry · 2011Review
- 5-HT receptors mediate lineage-dependent effects of serotonin on adult neurogenesis in Procambarus clarkii.Neural development · 2011Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Long-term sensitization training, or procedures that mimic the training, produces long-term facilitation of sensory-motor neuron synapses in Aplysia. The long-term effects of these procedures require mRNA and protein synthesis (Montarolo et al., 1986; Castellucci et al., 1989). Using the techniques of differential display reverse transcription PCR (DDRT-PCR) and ribonuclease protection assays (RPA), we identified a cDNA whose mRNA level was increased significantly in sensory neurons by treatments of isolated pleural-pedal ganglia with serotonin for 1.5 hr or by long-term behavioral training of Aplysia. The effects of serotonin and behavioral training on this mRNA were mimicked by treatments that elevate cAMP. The aplysia mRNA increased by serotonin and behavioral training was 41-45% identical to a developmentally regulated gene family which includes Drosophila tolloid and human bone morphogenetic protein-1 (BMP-1). Both tolloid and BMP-1 encode metalloproteases that might activate TGF-beta (transforming growth factor beta)-like molecules or process procollagens. Aplysia tolloid/BMP-1-like protein (apTBL-1) might regulate the morphology and efficacy of synaptic connections between sensory and motor neurons, which are associated with long-term sensitization.
Indexed as
Identifiers
8987797PMC6573248W2099875657What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.