ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1997
Heterogeneity of nicotinic receptor class and subunit mRNA expression among individual parasympathetic neurons from rat intracardiac ganglia.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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Who cites it
34 citing papers in PubMed, 121 citations in OpenAlex.
- Recording plasticity in neuronal activity in the rodent intrinsic cardiac nervous system using calcium imaging techniques.Frontiers in synaptic neuroscience · 2023Article
- Electrical properties and synaptic transmission in mouse intracardiac ganglion neurons in situ.Physiological reports · 2021Article
- Severe Hypoglycemia-Induced Fatal Cardiac Arrhythmias Are Mediated by the Parasympathetic Nervous System in Rats.Diabetes · 2019Article
- The expression of the nicotinic acetylcholine receptor α3 subunit in the brains of patients with Alzheimer's disease and its effects on α- and γ-secretases and Notch signal transduction in SH-SY5Y cells.International journal of clinical and experimental pathology · 2019Article
- Nicotinic acetylcholine receptors in neuropathic and inflammatory pain.FEBS letters · 2018Review
- The α3β4 nAChR partial agonist AT-1001 attenuates stress-induced reinstatement of nicotine seeking in a rat model of relapse and induces minimal withdrawal in dependent rats.Behavioural brain research · 2017Article
- Therapeutic concentrations of varenicline in the presence of nicotine increase action potential firing in human adrenal chromaffin cells.Journal of neurochemistry · 2017Article
- Evidence for the exclusive expression of functional homomeric α7 nAChRs in hypothalamic histaminergic tuberomammillary neurons in rats.Neuroscience letters · 2014Article
- Patterns of nicotinic receptor antagonism II: cardiovascular effects in rats.Drug and alcohol dependence · 2013Article
- Ro 32-0432 attenuates mecamylamine-precipitated nicotine withdrawal syndrome in mice.Naunyn-Schmiedeberg's archives of pharmacology · 2013Article
- Electrophysiological and pharmacological evaluation of the nicotinic cholinergic system in chagasic rats.BMC pharmacology & toxicology · 2013Article
- Quantitative biology of single neurons.Journal of the Royal Society, Interface · 2012Review
- AT-1001: a high affinity and selective α3β4 nicotinic acetylcholine receptor antagonist blocks nicotine self-administration in rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2012Article
- Novel α3β4 nicotinic acetylcholine receptor-selective ligands. Discovery, structure-activity studies, and pharmacological evaluation.Journal of medicinal chemistry · 2010Article
- Nicotinic receptor-based therapeutics and candidates for smoking cessation.Biochemical pharmacology · 2009Review
- Inhibition of alpha 7-containing nicotinic ACh receptors by muscarinic M1 ACh receptors in rat hippocampal CA1 interneurones in slices.The Journal of physiology · 2009Article
- Targeting reward-relevant nicotinic receptors in the discovery of novel pharmacotherapeutic agents to treat tobacco dependence.Nebraska Symposium on Motivation. Nebraska Symposium on Motivation · 2009Article
- Roles of nicotinic acetylcholine receptor beta subunits in function of human alpha4-containing nicotinic receptors.The Journal of physiology · 2006Article
- Feasibility of 2-deoxy-2-[18F]fluoro-D-glucose- A85380-PET for imaging of human cardiac nicotinic acetylcholine receptors in vivo.Clinical research in cardiology : official journal of the German Cardiac Society · 2006Article
- Selective modulation of neuronal nicotinic acetylcholine receptor channel subunits by Go-protein subunits.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Neurons have the potential to form thousands of distinct neuronal nicotinic receptors from the eight alpha and three beta subunits that currently are known. In an effort to determine how much of this potential complexity is realized among individual neurons, we examined the nicotinic pharmacological and biophysical properties and receptor subunit mRNA expression patterns in individual neurons cultured from rat epicardial ganglia. Analysis of the whole-cell pharmacology of these neurons showed a diversity of responses to the agonists acetylcholine, nicotine, cytisine, and 1,1-dimethyl-4-phenylpiperazinium, suggesting that a heterogeneous population of nicotinic receptor classes, or subtypes, is expressed by individual neurons. Single-channel analysis demonstrated three distinct conductances (18, 24, and 31 pS), with patches from different neurons containing different combinations of these channel classes. We used single-cell RT-PCR to examine nicotinic acetylcholine receptor (nAChR) subunit mRNA expression by individual neurons. Although mRNAs encoding all eight neuronal nAChR subunits for which we probed (alpha 2-alpha 5, alpha 7, beta 2-beta 4) were present in multicellular cultures, we found that individual epicardial neurons express distinct subsets of these nAChR subunit mRNAs. These results suggest that individual epicardial neurons express distinct arrays of nAChR subunits and that these subunits may assemble into functional receptors with distinct and variable subunit composition. This variable receptor subunit expression provides an explanation for the diversity of pharmacological and single-channel responses we have observed in individual neurons.
Indexed as
Identifiers
8987781PMC6573231W2130456914What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.