ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1997
Nerve growth factor induces apoptosis in human medulloblastoma cell lines that express TrkA receptors.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 118 citations in OpenAlex.
- TrkA activation sustains chemotherapy resistance in chemotolerant medulloblastoma cells.Acta neuropathologica communications · 2026Article
- Comparison of tyrosine kinase domain properties for the neurotrophin receptors TrkA and TrkB.The Biochemical journal · 2020Article
- Neurotrophin Signaling in Medulloblastoma.Cancers · 2020Review
- The Evolving Diagnostic and Treatment Landscape of NTRK-Fusion-Driven Pediatric Cancers.Paediatric drugs · 2020Review
- Activation of TRKA receptor elicits mastocytosis in mice and is involved in the development of resistance to KIT-targeted therapy.Oncotarget · 2017Article
- AAV-KLF7 Promotes Descending Propriospinal Neuron Axonal Plasticity after Spinal Cord Injury.Neural plasticity · 2017Article
- Characterization of novel biomarkers in selecting for subtype specific medulloblastoma phenotypes.Oncotarget · 2015Article
- Deregulated proliferation and differentiation in brain tumors.Cell and tissue research · 2015Review
- Dependence receptor TrkC is a putative colon cancer tumor suppressor.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- CARP-1 functional mimetics: a novel class of small molecule inhibitors of medulloblastoma cell growth.PloS one · 2013Article
- Mechanism for the induction of cell death in ONS-76 medulloblastoma cells by Zhangfei/CREB-ZF.Journal of neuro-oncology · 2012Article
- STK25 protein mediates TrkA and CCM2 protein-dependent death in pediatric tumor cells of neural origin.The Journal of biological chemistry · 2012Article
- Growth-inhibitory effect of neurotrophin-3-secreting adipose tissue-derived mesenchymal stem cells on the D283-MED human medulloblastoma cell line.Journal of neuro-oncology · 2012Article
- Necdin and neurotrophin receptors: interactors of relevance for neuronal resistance to oxidant stress.Pediatric research · 2011Article
- Effects of castration on the expression of the NGF and TrkA in the vas deferens and accessory male genital glands of the rat.European journal of histochemistry : EJH · 2009Article
- Necdin and TrkA contribute to modulation by p75NTR of resistance to oxidant stress.Experimental cell research · 2009Article
- Zhangfei induces the expression of the nerve growth factor receptor, trkA, in medulloblastoma cells and causes their differentiation or apoptosis.Journal of neuro-oncology · 2009Article
- Neurotrophin receptors expression and JNK pathway activation in human astrocytomas.BMC cancer · 2007Article
- Emerging treatments and gene expression profiling in high-risk medulloblastoma.Paediatric drugs · 2007Review
- Recent advances in embryonal tumours of the central nervous system.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2005Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neurotrophins act through their cognate receptors to promote the differentiation and/or survival of neuronal progenitor cells, immature neurons, and other cells. Here, we examined the effects of nerve growth factor (NGF) and its cognate receptor (Trk or TrkA) on the survival of a common childhood brain tumor, i.e., medulloblastoma, a tumor that resembles CNS neuroepithelial progenitor cells. To do this, we engineered two human medulloblastoma cell lines (i.e., D283MED and DAOY cells) to express human TrkA using a retroviral expression vector. Surprisingly, NGF-treated medulloblastoma cells expressing the TrkA receptor (D283trk and DAOYtrk cells) grown in the presence or absence of serum underwent massive apoptosis, but similar treatment did not induce apoptosis in wild-type uninfected cells, cells expressing an empty vector, or cells expressing the TrkC receptor. Furthermore, D283MED cells engineered to express the human p75 NGF receptor (D283p75) also did not undergo apoptosis. Significantly, NGF-induced apoptosis in D283trk and DAOYtrk cells can be inhibited by anti-NGF antibodies and by K-252a, an inhibitor of TrkA tyrosine phosphorylation and mimicked by high concentrations of NT3. Because NGF treatment primarily eliminated D283trk cells from the S phase of the cell cycle, this form of NGF-mediated apoptosis is cell cycle-dependent. These findings suggest that a NGF/TrkA signal transduction pathway could activate apoptotic cell death programs in CNS neuroepithelial progenitor cells and in childhood brain tumors.
Indexed as
Identifiers
8987776PMC6573234W1953570960What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.