ArticlePharmaceutical research1996
A new method for diffusion measurement in polymeric films based on a stacked sheet concept.
Article in Pharmaceutical research, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
3 authors.
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Abstract
purposeTo develop and evaluate a simple, yet well defined, method to measure diffusion in semi-solids, i.e. polymeric materials.
methodsThe method was based on a concept where equivalent discs of polymeric films were cut and stacked on top of each other. The diffusion process was allowed to proceed unidimensionally through the stack of films perpendicular to the film surface. After an appropriate time, the stack was analysed disc by disc with respect to solute content and from the concentration profile so obtained the diffusion coefficient was calculated.
resultsAn all-in-one device was developed, manufactured in stainless-steel, that cuts circular discs and stores each one successively in a "stack" in the cell compartment.
conclusionsData from a silicone based system shows that the method, although simple, is accurate and reproducible.
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Registered trials
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