ArticlePharmaceutical research1996
Anionic gels as vehicles for electrically-modulated drug delivery. I. Solvent and drug transport phenomena.
Article in Pharmaceutical research, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed, 31 citations in OpenAlex.
- Stimuli-Responsive Biomaterials for Vaccines and Immunotherapeutic Applications.Advanced therapeutics · 2020Article
- Characteristic of Gelatine, Carrageenan and Sodium Alginate Hydrosols Treated by Direct Electric Current.Polymers · 2016Article
- Physicochemical Properties of Biopolymer Hydrogels Treated by Direct Electric Current.Polymers · 2016Article
- Stimulus-responsive hydrogels: Theory, modern advances, and applications.Materials science & engineering. R, Reports : a review journal · 2015Article
- Cross-linked poly(acrylic acids) microgels and agarose as semi-interpenetrating networks for resveratrol release.Journal of materials science. Materials in medicine · 2015Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe purpose of this study was to elucidate the in vitro behavior of anionic gels as formulation matrices for electrically-modulated drug delivery. Agarose and combinations of agarose with other anionic polymers (carbomer 934P; xanthan gum) were selected and tested to evaluate their potential for drug delivery.
methodsElectrical current was applied by an automatic crossover power supply to minimize the current fluctuation. Hydrocortisone was selected as the model drug in order to minimize electrostatic interference with drug transport. Syneresis and drug migration were evaluated as a function of current application time and the intensity of electrical current.
resultsThe data show that electrical current strength and gellant content can affect both the syneresis and drug migration. A linear correlation was found between hydrocortisone loss and mass loss via the exudate. Moreover, in agarose-carbomer 934P gel systems, cumulative gel mass loss is a linear function of time at low intensities of electrical current (e.g., 0.5 mA and 1 mA). However, hydrocortisone distribution, after electrical application, is relatively asymmetric in those agarose-carbomer 934P gels (and in agarose-xanthan gum gels) in contrast to gel matrices containing only agarose.
conclusionsIn this study, the use of carbomer 934P in conjunction with agarose enables the formulator to achieve zero-order release with electrical application. Increased anisotropicity of a gel system due to the application of electrical current could alter the effectiveness of a drug delivery system.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.