ArticleProceedings of the National Academy of Sciences of the United States of America1996
A novel modifier gene for plasma von Willebrand factor level maps to distal mouse chromosome 11.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 63 citations in OpenAlex.
- Hyperadhesive von Willebrand Factor Contributes to Pathogenesis of Preeclampsia.Arteriosclerosis, thrombosis, and vascular biology · 2026Article
- Increased galactose expression and enhanced clearance in patients with low von Willebrand factor.Blood · 2019Article
- Functional Consequences of Mannose and Asialoglycoprotein Receptor Ablation.The Journal of biological chemistry · 2016Article
- Expression of the Blood-Group-Related Gene B4galnt2 Alters Susceptibility to Salmonella Infection.PLoS pathogens · 2015Article
- Development and in vivo evaluation of small-diameter vascular grafts engineered by outgrowth endothelial cells and electrospun chitosan/poly(ε-caprolactone) nanofibrous scaffolds.Tissue engineering. Part A · 2014Article
- Animal models of hemophilia and related bleeding disorders.Seminars in hematology · 2013Review
- Article
- ADAMTS13 deficiency exacerbates VWF-dependent acute myocardial ischemia/reperfusion injury in mice.Blood · 2012Article
- Spontaneous Irs1 passenger mutation linked to a gene-targeted SerpinB2 allele.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Selection on cis-regulatory variation at B4galnt2 and its influence on von Willebrand factor in house mice.Molecular biology and evolution · 2009Article
- Quantitative trait locus analysis for hemostasis and thrombosis.Mammalian genome : official journal of the International Mammalian Genome Society · 2008Article
- The combined roles of ADAMTS13 and VWF in murine models of TTP, endotoxemia, and thrombosis.Blood · 2008Article
- The endothelial-specific regulatory mutation, Mvwf1, is a common mouse founder allele.Mammalian genome : official journal of the International Mammalian Genome Society · 2008Article
- Genetic regulation of plasma von Willebrand factor levels: quantitative trait loci analysis in a mouse model.Journal of thrombosis and haemostasis : JTH · 2007Article
- Enhanced VWF biosynthesis and elevated plasma VWF due to a natural variant in the murine Vwf gene.Blood · 2006Article
- Shigatoxin triggers thrombotic thrombocytopenic purpura in genetically susceptible ADAMTS13-deficient mice.The Journal of clinical investigation · 2005Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Type 1 von Willebrand disease (VWD), characterized by reduced levels of plasma von Willebrand factor (VWF), is the most common inherited bleeding disorder in humans. Penetrance of VWD is incomplete, and expression of the bleeding phenotype is highly variable. In addition, plasma VWF levels vary widely among normal individuals. To identify genes that influence VWF level, we analyzed a genetic cross between RIIIS/J and CASA/Rk, two strains of mice that exhibit a 20-fold difference in plasma VWF level. DNA samples from F2 progeny demonstrating either extremely high or extremely low plasma VWF levels were pooled and genotyped for 41 markers spanning the autosomal genome. A novel locus accounting for 63% of the total variance in VWF level was mapped to distal mouse chromosome 11, which is distinct from the murine Vwf locus on chromosome 6. We designated this locus Mvwf for "modifier of VWF." Additional genotyping of as many as 2407 meioses established a high resolution genetic map with gene order Cola1-Itg3a-Ngfr-Mvwf/Gip-Hoxb9-Hoxb1++ +-Cbx'rs2-Cox5a-Gfap. The Mvwf candidate interval between Ngfr and Hoxb9 is approximately 0.5 centimorgan (cM). These results demonstrate that a single dominant gene accounts for the low VWF phenotype of RIIIS/J mice in crosses with several other strains. The pattern of inheritance suggests a gain-of-function mutation in a unique component of VWF biosynthesis or processing. Characterization of the human homologue for Mvwf may have relevance for a subset of type 1 VWD cases and may define an important genetic factor modifying penetrance and expression of mutations at the VWF locus.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.