ArticleProceedings of the National Academy of Sciences of the United States of America1996
Characterization of avian T-cell receptor gamma genes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 74 citations in OpenAlex.
- Chicken γδ T cells proliferate upon IL-2 and IL-12 treatment and show a restricted receptor repertoire in cell culture.Frontiers in immunology · 2024Article
- Unraveling the chicken T cell repertoire with enhanced genome annotation.Frontiers in immunology · 2024Article
- Development and characterization of a CRISPR/Cas9-mediatedFrontiers in immunology · 2022Article
- Article
- Characterization of the chicken T cell receptor γ repertoire by high-throughput sequencing.BMC genomics · 2021Article
- The Chicken Embryo Model: A Novel and Relevant Model for Immune-Based Studies.Frontiers in immunology · 2021Review
- Review
- A comprehensive analysis of the germline and expressed TCR repertoire in White Peking duck.Scientific reports · 2017Article
- Identification and characterization of TCRγ and TCRδ chains in channel catfish, Ictalurus punctatus.Immunogenetics · 2014Article
- The immune gene repertoire of an important viral reservoir, the Australian black flying fox.BMC genomics · 2012Article
- Molecular mechanisms that control mouse and human TCR-alphabeta and TCR-gammadelta T cell development.Seminars in immunopathology · 2008Review
- Characterization of the T-cell receptor gamma locus and analysis of the variable gene segment expression in rabbit.Immunogenetics · 2005Article
- Identification of a novel cytokine-like transcript differentially expressed in avian gammadelta T cells.Immunogenetics · 2004Article
- Evolution of TRG clusters in cattle and sheep genomes as drawn from the structural analysis of the ovine TRG2@ locus.Journal of molecular evolution · 2003Article
- T cell receptor gene deletion circles identify recent thymic emigrants in the peripheral T cell pool.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Ontogeny of the immune system: gamma/delta and alpha/beta T cells migrate from thymus to the periphery in alternating waves.The Journal of experimental medicine · 1997Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
In birds and mammals T cells develop along two discrete pathways characterized by expression of either the alpha beta or the gamma delta T-cell antigen receptors (TCRs). To gain further insight into the evolutionary significance of the gamma delta T-cell lineage, the present studies sought to define the chicken TCR gamma locus. A splenic cDNA library was screened with two polymerase chain reaction products obtained from genomic DNA using primers for highly conserved regions of TCR and immunoglobulin genes. This strategy yielded cDNA clones with characteristics of mammalian TCR gamma chains, including canonical residues considered important for proper folding and stability. Northern blot analysis with the TCR gamma cDNA probe revealed 1.9-kb transcripts in the thymus, spleen, and a gamma delta T-cell line, but not in B or alpha beta T-cell lines. Three multimember V gamma subfamilies, three J gamma gene segments, and a single constant region C gamma gene were identified in the avian TCR gamma locus. Members of each of the three V gamma subfamilies were found to undergo rearrangement in parallel during the first wave of thymocyte development. TCR gamma repertoire diversification was initiated on embryonic day 10 by an apparently random pattern of V-J gamma recombination, nuclease activity, and P-and N-nucleotide additions to generate a diverse repertoire of avian TCR gamma genes early in ontogeny.
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