ArticleProceedings of the National Academy of Sciences of the United States of America1996
Microtubule reorganization is obligatory for growth cone turning.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed, 131 citations in OpenAlex.
- Oscillatory dynamics in paclitaxel-proteinoid networks.Discover molecules · 2026Article
- Preference of CAMSAP3 for expanded microtubule lattice contributes to stabilization of the minus end.Life science alliance · 2023Article
- Growth cone macropinocytosis of neurotrophin receptor and neuritogenesis are regulated by neuron navigator 1.Molecular biology of the cell · 2022Article
- With the Permission of Microtubules: An Updated Overview on Microtubule Function During Axon Pathfinding.Frontiers in molecular neuroscience · 2021Review
- Mechanistic advances in axon pathfinding.Current opinion in cell biology · 2020Review
- The role of nonmuscle myosin 2A and 2B in the regulation of mesenchymal cell contact guidance.Molecular biology of the cell · 2019Article
- STIM1 Is Required for Remodeling of the Endoplasmic Reticulum and Microtubule Cytoskeleton in Steering Growth Cones.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Knockdown of Fidgetin Improves Regeneration of Injured Axons by a Microtubule-Based Mechanism.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Model for Coordination of Microtubule and Actin Dynamics in Growth Cone Turning.Frontiers in cellular neuroscience · 2018Article
- The microtubule plus-end-tracking protein TACC3 promotes persistent axon outgrowth and mediates responses to axon guidance signals during development.Neural development · 2017Article
- Cytoskeletal social networking in the growth cone: How +TIPs mediate microtubule-actin cross-linking to drive axon outgrowth and guidance.Cytoskeleton (Hoboken, N.J.) · 2016Review
- Filamin A is required in injured axons for HDAC5 activity and axon regeneration.The Journal of biological chemistry · 2015Article
- Collapsin response mediator protein 4 regulates growth cone dynamics through the actin and microtubule cytoskeleton.The Journal of biological chemistry · 2014Article
- Ena/VASP regulates mDia2-initiated filopodial length, dynamics, and function.Molecular biology of the cell · 2014Article
- A novel role for doublecortin and doublecortin-like kinase in regulating growth cone microtubules.Human molecular genetics · 2012Article
- Microtubule plus-end tracking proteins SLAIN1/2 and ch-TOG promote axonal development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Microtubule redistribution in growth cones elicited by focal inactivation of kinesin-5.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Regulation of axonal outgrowth and pathfinding by integrin-ECM interactions.Developmental neurobiology · 2011Review
- The growth cone cytoskeleton in axon outgrowth and guidance.Cold Spring Harbor perspectives in biology · 2011Review
- Clasp-mediated microtubule bundling regulates persistent motility and contact repulsion in Drosophila macrophages in vivo.The Journal of cell biology · 2010Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To examine the role of microtubules in growth cone turning, we have compared the microtubule organization in growth cones advancing on uniform laminin substrates with their organization in growth cones turning at a laminin-tenascin border. The majority (82%) of growth cones on laminin had a symmetrical microtubule organization, in which the microtubules entering the growth cone splay out toward the periphery of the growth cone. Growth cones at tenascin borders had symmetrically arranged microtubules in only 34% of cases, whereas in the majority of cases the microtubules were displaced toward one-half of the growth cone, presumably stabilizing in the direction of the turn along the tenascin border. These results suggest that reorganization of microtubules could underlie growth cone turning. Further evidence for the involvement of microtubule rearrangement in growth cone turning was provided by experiments in which growth cones approached tenascin borders in the presence of nanomolar concentrations of the microtubule stabilizing compound, Taxol. Taxol altered the organization of microtubules in growth cones growing on laminin by restricting their distribution to the proximal regions of the growth cone and increasing their bundling. Taxol did not stop growth cone advance on laminin. When growing in the presence of Taxol, growth cones at tenascin borders were not able to turn and grow along the laminin-tenascin border, and consequently stopped at the border. Growth cones were arrested at borders for as long as Taxol was present (up to 6 h) without showing any signs of drug toxicity. These effects of Taxol were reversible. Together, these results suggest that microtubule reorganization in growth cones is a necessary event in growth cone turning.
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