ArticleHistochemistry and cell biology1996
FA1 immunoreactivity in endocrine tumours and during development of the human fetal pancreas; negative correlation with glucagon expression.
Article in Histochemistry and cell biology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 58 citations in OpenAlex.
- Overexpression of Pref-1 in pancreatic islet β-cells in mice causes hyperinsulinemia with increased islet mass and insulin secretion.Biochemical and biophysical research communications · 2015Article
- Cellular and molecular mechanisms underlying oxygen-dependent radiosensitivity.Radiation research · 2015Review
- The Missing lnc(RNA) between the pancreatic β-cell and diabetes.Frontiers in genetics · 2014Review
- Interaction of delta-like 1 homolog (Drosophila) with prohibitins and its impact on tumor cell clonogenicity.Molecular cancer research : MCR · 2014Article
- Hypoxia and regulation of cancer cell stemness.Advances in experimental medicine and biology · 2014Review
- Pituitary phenotypes of mice lacking the notch signalling ligand delta-like 1 homologue.Journal of neuroendocrinology · 2013Article
- Conditional deletions refine the embryonic requirement for Dlk1.Mechanisms of development · 2013Article
- DLK1, delta-like 1 homolog (Drosophila), regulates tumor cell differentiation in vivo.Cancer letters · 2012Article
- Article
- Effect of retinoic acid and delta-like 1 homologue (DLK1) on differentiation in neuroblastoma.Nutrition research and practice · 2010Article
- Impact of the hypoxic tumor microenvironment on the regulation of cancer stem cell characteristics.Cancer biology & therapy · 2010Review
- The imprinted DLK1-MEG3 gene region on chromosome 14q32.2 alters susceptibility to type 1 diabetes.Nature genetics · 2010Article
- Hypoxia-regulated delta-like 1 homologue enhances cancer cell stemness and tumorigenicity.Cancer research · 2009Article
- DLK is a novel immunohistochemical marker for adrenal gland tumors.Virchows Archiv : an international journal of pathology · 2009Article
- Delta-like protein (DLK) is a novel immunohistochemical marker for human hepatoblastomas.Virchows Archiv : an international journal of pathology · 2008Article
- Article
- Imprinting, expression, and localisation of DLK1 in Wilms tumours.Journal of clinical pathology · 2005Article
- Transit-amplifying ductular (oval) cells and their hepatocytic progeny are characterized by a novel and distinctive expression of delta-like protein/preadipocyte factor 1/fetal antigen 1.The American journal of pathology · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fetal antigen 1 (FA1) is a glycoprotein containing six epidermal growth factor (EGF)-like repeats. It is closely similar to the protein translated from the human delta-like (dlk) cDNA and probably constitutes a proteolytically processed form of dlk. dlk is homologous to the Drosophila homeotic proteins delta and notch and to the murine preadipocyte differentiation factor Pref-1. These proteins participate in determining cell fate choices during differentiation. We now report that FA1 immunoreactivity is present in a number of neuroectodermally derived tumours as well as in pancreatic endocrine tumours. A negative correlation between FA1 and glucagon immunoreactants in these tumours prompted a reexamination of FA1 immunoreactants during fetal pancreatic development. At the earliest stages of development, FA1 was expressed by most of the non-endocrine parenchymal cells and, with ensuing development, gradually disappeared from these cells and became restricted to insulin-producing beta cells. Throughout development FA1 was not detected in endocrine glucagon, somatostatin or pancreatic polypeptide cells. Moreover, developing insulin cells that coexpressed glucagon were negative for FA1. Thus, there was a negative correlation between FA1 and glucagon both in tumours and during development. These results, together with FA1/dlk's similarity with homeotic proteins, point to a role of FA1 in islet cell differentiation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.