Evidence map›Paper›PMID 8982376›Full record

ArticleVirchows Archiv : an international journal of pathology1996

Prognostic criteria in nonfunctioning pancreatic endocrine tumours.

S La Rosa, F Sessa, C Capella, C Riva, B E Leone, C Klersy, G Rindi, E Solcia

Abstract read
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In one paragraph

Article in Virchows Archiv : an international journal of pathology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 1 pooled it
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 1 synthesis or guideline pooled it, 248 citations in OpenAlex.

  1. Guideline
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  5. Classification of neuroendocrine neoplasms: lights and shadows.Reviews in endocrine & metabolic disorders · 2021
    Review
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  20. Ki-67 is a reliable pathological grading marker for neuroendocrine tumors.Virchows Archiv : an international journal of pathology · 2013
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

S La RosaDepartment of Clinical and Biological Sciences, University of Pavia at Varese, Italy.
F Sessa
C Capella
C Riva
B E Leone
C Klersy
G Rindi
E Solcia
University of Pavia · ITFondazione Audiologica Varese · ITIstituti di Ricovero e Cura a Carattere Scientifico · ITSan Raffaele University of Rome · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To identify prognostic subgroups among non-functioning (nonsyndromic) pancreatic endocrine tumours, a series of 61 tumours were analysed systematically for macroscopic, histopathological and immunohistochemical variables potentially predictive of malignancy. High-grade nuclear atypia, elevated mitotic rate and multifocal necrosis allowed us to separate 5 poorly differentiated carcinomas from 56 well differentiated tumours. Among the latter, 29 well-differentiated carcinomas showing gross local invasion or metastases were identified. Vascular or perineural microinvasion, Ki67 proliferative index > 2%, mitotic rate > or = 2, size > or = 4 cm, capsular penetration, nuclear atypia, lack of progesterone receptors and presence of calcitonin were among the variables correlated with malignancy. The first two were the most sensitive and specific. Their presence or absence was used in the 27 tumours lacking evidence of malignancy at the time of surgery to separate 11 cases with increased risk of malignancy (in 2 of which metastases developed during follow-up) from 16 cases with limited risk. The resulting four prognostic groups of non-functioning pancreatic endocrine tumours (limited- and increased-risk tumours, well-differentiated carcinomas and poorly differentiated carcinomas) showed distinct survival curves, which were significantly affected by vascular microinvasion, Ki67 proliferative index and metastases.

Indexed as

AdultAgedCarcinomaEndocrine Gland NeoplasmsFemaleHumansImmunohistochemistryKi-67 AntigenMaleMiddle AgedMitosisNecrosisNeoplasm InvasivenessPancreatic NeoplasmsPrognosisRisk FactorsKi-67 Antigen

Identifiers

PMID8982376
OpenAlexW2021029245

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.