ArticleNeuron1996
Lack of neurotrophin-3 results in death of spinal sensory neurons and premature differentiation of their precursors.
Article in Neuron, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
79 citing papers in PubMed, 235 citations in OpenAlex.
- Peripheral neuronal sensitization and neurovascular remodelling in osteoarthritis pain.Nature reviews. Rheumatology · 2025Review
- The making of a proprioceptor: a tale of two identities.Trends in neurosciences · 2023Review
- Influencers in the Somatosensory System: Extrinsic Control of Sensory Neuron Phenotypes.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2023Review
- A developmental atlas of somatosensory diversification and maturation in the dorsal root ganglia by single-cell mass cytometry.Nature neuroscience · 2022Article
- Selective disruption of trigeminal sensory neurogenesis and differentiation in a mouse model of 22q11.2 deletion syndrome.Disease models & mechanisms · 2022Article
- Metabolic Control of Sensory Neuron Survival by the p75 Neurotrophin Receptor in Schwann Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Loss of Elp1 perturbs histone H2A.Z and the Notch signaling pathway.Biology open · 2021Article
- Regulating muscle spindle and Golgi tendon organ proprioceptor phenotypes.Current opinion in physiology · 2021Article
- NT3/TrkC Pathway Modulates the Expression of UCP-1 and Adipocyte Size in Human and Rodent Adipose Tissue.Frontiers in endocrinology · 2021Article
- Intrinsic control of neuronal diversity and synaptic specificity in a proprioceptive circuit.eLife · 2020Article
- The essentials of developmental apoptosis.F1000Research · 2020Review
- Tropomyosin receptor kinase (TRK) biology and the role of NTRK gene fusions in cancer.Annals of oncology : official journal of the European Society for Medical Oncology · 2019Review
- Muscle-selective RUNX3 dependence of sensorimotor circuit development.Development (Cambridge, England) · 2019Article
- A cell fitness selection model for neuronal survival during development.Nature communications · 2019Article
- Temporally restricted death and the role of p75NTR as a survival receptor in the developing sensory nervous system.Developmental neurobiology · 2018Article
- Elongator and codon bias regulate protein levels in mammalian peripheral neurons.Nature communications · 2018Article
- The adaptor protein GULP promotes Jedi-1-mediated phagocytosis through a clathrin-dependent mechanism.Molecular biology of the cell · 2014Article
- BDNF signaling and survival of striatal neurons.Frontiers in cellular neuroscience · 2014Review
- Loss of neurotrophin-3 from smooth muscle disrupts vagal gastrointestinal afferent signaling and satiation.American journal of physiology. Regulatory, integrative and comparative physiology · 2013Article
- Familial dysautonomia model reveals Ikbkap deletion causes apoptosis of Pax3+ progenitors and peripheral neurons.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
19 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
To understand mechanisms resulting in the absence of two-thirds of spinal sensory neurons in mice lacking NT-3, we have compared dorsal root ganglia development in normal and mutant embryos. The reduction in neurons, achieved by E13, results from several deficits: first, elevated neuronal apoptosis significantly reduces neuronal numbers; second, elevated neurogenesis between E11 and E12, without changes in rates of precursor proliferation or apoptosis, depletes the precursor pool; consequently, the reduced precursor pool prevents increases in neuronal numbers between E12 and E13, when most neurons are born in normal animals. Although deficits occur before final target innervation, we show that NT-3 is expressed at all stages in regions accessible to these neurons or their axons and is only restricted to final targets after innervation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.