ArticleAmerican journal of human genetics1997
Evidence of a non-MHC susceptibility locus in type I diabetes linked to HLA on chromosome 6.
Article in American journal of human genetics, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 95 citations in OpenAlex.
- Association between KIR gene polymorphisms and type 1 diabetes mellitus (T1DM) susceptibility: A PRISMA-compliant meta-analysis.Medicine · 2017Pooled it
- Hypomethylation within gene promoter regions and type 1 diabetes in discordant monozygotic twins.Journal of autoimmunity · 2016Article
- Combining family- and population-based imputation data for association analysis of rare and common variants in large pedigrees.Genetic epidemiology · 2014Article
- From markers to molecular mechanisms: type 1 diabetes in the post-GWAS era.The review of diabetic studies : RDS · 2012Review
- Tests for genetic interactions in type 1 diabetes: linkage and stratification analyses of 4,422 affected sib-pairs.Diabetes · 2011Article
- Incorporation of covariates in simultaneous localization of two linked loci using affected relative pairs.BMC genetics · 2010Article
- Genome-wide scan for linkage to type 1 diabetes in 2,496 multiplex families from the Type 1 Diabetes Genetics Consortium.Diabetes · 2009Article
- Conditional tests for localizing trait genes.Human heredity · 2009Article
- Heat-shock protein gene is not associated with type-1 diabetes in African Americans.Journal of the National Medical Association · 2007Article
- Integrative analysis for finding genes and networks involved in diabetes and other complex diseases.Genome biology · 2007Article
- Immunogenetics of Hashimoto's thyroiditis.Journal of autoimmune diseases · 2005Article
- Genes mediating environment interactions in type 1 diabetes.The review of diabetic studies : RDS · 2005Article
- Fine mapping of a region on chromosome 21q21.11-q22.3 showing linkage to type 1 diabetes.Journal of medical genetics · 2005Article
- Common and unique susceptibility loci in Graves and Hashimoto diseases: results of whole-genome screening in a data set of 102 multiplex families.American journal of human genetics · 2003Article
- Evidence for a locus (IDDM16) in the immunoglobulin heavy chain region on chromosome 14q32.3 producing susceptibility to type 1 diabetes.Genes and immunity · 2002Article
- A genome-wide screen for linkage in Nordic sib-pairs with multiple sclerosis.Genes and immunity · 2002Article
- Genetics of type 1 diabetes mellitus.Genes and immunity · 2002Review
- A genomewide scan for type 1-diabetes susceptibility in Scandinavian families: identification of new loci with evidence of interactions.American journal of human genetics · 2001Article
- Seven regions of the genome show evidence of linkage to type 1 diabetes in a consensus analysis of 767 multiplex families.American journal of human genetics · 2001Article
- Partial paternal uniparental disomy of chromosome 6 in an infant with neonatal diabetes, macroglossia, and craniofacial abnormalities.American journal of human genetics · 2000Article
Corrections and comments
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Authors and funding
13 authors at 1 institution in 1 country.
Funding
Abstract
Linkage studies have led to the identification of several chromosome regions that may contain susceptibility loci to type I diabetes (IDDM), in addition to the HLA and INS loci. These include two on chromosome 6q, denoted IDDM5 and IDDM8, that are not linked to HLA. In a previous study, we noticed that the evidence for linkage to IDDM susceptibility around the HLA locus extended over a total distance of 100 cM, which suggested to us that another susceptibility locus could reside near HLA. We developed a statistical method to test this hypothesis in a panel of 523 multiplex families from France, the United States, and Denmark (a total of 667 affected sib pairs, 536 with both parents genotyped), and here present evidence (P = .00003) of a susceptibility locus for IDDM located 32 cM from HLA in males but not linked to HLA in females and distinct from IDDM5 and IDDM8. A new statistical method to test for the presence of a second susceptibility locus linked to a known first susceptibility locus (here HLA) is presented. In addition, we analyzed our current family panel with markers for IDDM5 and IDDM8 on chromosome 6 and found suggestions of linkage for both of these loci (P = .002 and .004, respectively, on the complete family panel). When cumulated with previously published results, with overlapping families removed, the affected-sib-pair tests had a significance of P = .0001 for IDDM5 and P = .00004 for IDDM8.
Indexed as
Identifiers
8981961PMC1712534W154663569What OpenQuestion holds
Registered trials
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