Multiple changes in oncogenes and tumor suppressor genes in human retinoblastoma.

R O Howard

Abstract read

In one paragraph

Article in Transactions of the American Ophthalmological Society, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact, top 98% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

Array comparative genomic hybridization in retinoma and retinoblastoma tissues.Cancer science · 2009
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

R O HowardDepartment of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, Connecticut, USA.

Yale University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo present data to support the hypothesis that human retinoblastoma tumors form by a multistep process.

methodsSurvey of the karyotype of 90 human retinoblastomas, with emphasis on changes in chromosomal regions known to contain oncogenes and tumor suppressor genes.

conclusionThe data support the hypothesis that retinoblastoma occurs after multiple and often varied steps, similar to other human malignancies.

Indexed as

Chromosome BandingChromosome MappingEye NeoplasmsGene DosageGenes, rasGenes, Tumor SuppressorHumansKaryotypingRetinoblastoma

Identifiers

PMID8981702

PMCPMC1312101

OpenAlexW163448390

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.