ArticleGlycoconjugate journal1996
Molecular basis for erythrocyte Le(a+ b+) and salivary ABH partial-secretor phenotypes: expression of a FUT2 secretor allele with an A-->T mutation at nucleotide 385 correlates with reduced alpha(1,2) fucosyltransferase activity.
Article in Glycoconjugate journal, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 81 citations in OpenAlex.
- Genetic Variations of theMedical sciences (Basel, Switzerland) · 2025Article
- Characterization of blood group variants in an Omani population by comparison of whole genome sequencing and serology.Transfusion · 2025Article
- H and B Blood Antigens Are Essential for In Vitro Replication of GII.2 Human Norovirus.Open forum infectious diseases · 2025Article
- Secretor status is a modifier of vaginal microbiota-associated preterm birth risk.Microbial genomics · 2024Article
- Characterization of Blood Group Variants in an Omani Population by Comparison of Whole Genome Sequencing and Serology.bioRxiv : the preprint server for biology · 2024Article
- Diagnostic Performance of a Tumor Marker Gene Test to Personalize Serum CA19-9 Reference Ranges.Clinical cancer research : an official journal of the American Association for Cancer Research · 2023Article
- Human Milk Oligosaccharide Profiles and the Secretor and Lewis Gene Status of Indonesian Lactating Mothers.Pediatric gastroenterology, hepatology & nutrition · 2023Article
- Detection of c.375A>G, c.385A>T, c.571C>T, andDiagnostics (Basel, Switzerland) · 2023Article
- Estimation of Lewis Blood Group Status by Fluorescence Melting Curve Analysis in Simultaneous Genotyping of c.385A>T and Fusion Gene inDiagnostics (Basel, Switzerland) · 2023Article
- FUT2 gene as a genetic susceptible marker of infectious diseases: A Review.International journal of molecular epidemiology and genetics · 2022Review
- Survey and characterization of nonfunctional alleles of FUT2 in a database.Scientific reports · 2021Article
- Four Non-functionalIranian journal of public health · 2018Article
- Article
- Fucosyltransferase 2: a genetic risk factor for primary sclerosing cholangitis and Crohn's disease--a comprehensive review.Clinical reviews in allergy & immunology · 2015Review
- The G428A nonsense mutation in FUT2 provides strong but not absolute protection against symptomatic GII.4 Norovirus infection.PloS one · 2009Article
- Evolution of human calicivirus RNA in vivo: accumulation of mutations in the protruding P2 domain of the capsid leads to structural changes and possibly a new phenotype.Journal of virology · 2003Article
- DNA sequence variation of the human ABO-secretor locus ( FUT2) in New Guinean populations: possible early human migration from Africa.Human genetics · 2003Article
- Structural and immunochemical identification of Le(a), Le(b), H type 1, and related glycolipids in small intestinal mucosa of a group O Le(a-b-) nonsecretor.Glycoconjugate journal · 1997Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The SewA385T mutation of the FUT2 gene was found to correlate with both the erthrocyte Le(a + b+) and/or salivary ABH partial-secretor phenotypes of Polynesians. Constructs with FUT1 and FUT2 wild type genes, and the FUT2 SewA385T, seG428A and seC571T mutated alleles, were cloned into pcDNAI, and expressed in COS-7 cells. COS-7 cells transfected with the SewA385T allele had weak, but detectable, alpha(1,2)fucosyltransferase activity, with an acceptor substrate pattern similar to the wild type FUT2 gene. Comparative kinetic studies from cell extracts with mutated SewA385T and wild type FUT2 alleles gave similar Km values, but less enzyme activity was present in cells transfected with SewA385T (Vmax 230 pmol h-1 mg-1), as compared to those transfected with FUT2 (Vmax 1030 pmol h-1 mg-1), suggesting that the mutated enzyme is more unstable. These results confirm that the molecular basis for the erythrocyte Le(a + b+), and the associated ABH salivary partial-secretor phenotype, is an amino acid change of Ile129-->Phe in the secretor alpha(1,2)fucosyltransferase.
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