ArticleBritish journal of cancer1996
The expression and localisation of beta-nerve growth factor (beta-NGF) in benign and malignant human prostate tissue: relationship to neuroendocrine differentiation.
Article in British journal of cancer, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 32 citations in OpenAlex.
- Anticancer Effect of Cathelicidin LL-37, Protegrin PG-1, Nerve Growth Factor NGF, and Temozolomide: Impact on the Mitochondrial Metabolism, Clonogenic Potential, and Migration of Human U251 Glioma Cells.Molecules (Basel, Switzerland) · 2022Article
- Expression of nerve growth factor in the prostate of male rats in response to chronic stress and sympathetic denervation.Experimental and therapeutic medicine · 2014Article
- Effects of castration on the expression of the NGF and TrkA in the vas deferens and accessory male genital glands of the rat.European journal of histochemistry : EJH · 2009Article
- Role of neurotrophins and neurotrophins receptors in the in vitro invasion and heparanase production of human prostate cancer cells.Clinical & experimental metastasis · 1999Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
beta-NGF is a determinant of sympathetic innervation and a neural differentiation factor. In the present study, we have examined 15 benign prostatic hyperplastic and 15 prostate cancer patients for the expression and localisation of beta-NGF by reverse transcription-polymerase chain reaction (RT-PCR), Western blotting, immunohistochemistry and ELISA. We have correlated the beta-NGF concentrations to prostate morphometry and neuroendocrine differentiation. The presence of beta NGF mRNA transcripts was confirmed by RT-PCR where a 542 bp product was found with specific primers for the human beta-NGF cDNA sequence. The presence of the peptide was also confirmed by Western blot analysis which showed a protein co-migrating with recombinant human beta-NGF. Our results demonstrate that beta-NGF is localised to prostate epithelium, and the concentrations of the peptide were not significantly different in malignant (mean +/- s.d.; 3100 +/- 1502 pg g-1 wet weight of tissue) than in benign tissues (1992 +/- 684 pg g-1, P = 0.512). We were, however, unable to correlate the concentrations of beta-NGF to neuroendocrine differentiation in malignant tissues. Clearly, the present study demonstrates that beta-NGF is a product of the prostate and may be involved in the control of the sympathetic innervation of the human prostate.
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