ArticleBritish journal of cancer1996
In vivo experimental evidence that the nitric oxide pathway is involved in the X-ray-induced antiangiogenicity.
Article in British journal of cancer, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 34 citations in OpenAlex.
- Deep models of integrated multiscale molecular data decipher the endothelial cell response to ionizing radiation.iScience · 2022Article
- Histological assessment of the local effect of different concentrations of aminoguanidine hydrochloride on bone healing in rats.Dental research journal · 2021Article
- Review
- Optimal treatment scheduling of ionizing radiation and sunitinib improves the antitumor activity and allows dose reduction.Cancer medicine · 2015Article
- The chicken chorioallantoic membrane model in biology, medicine and bioengineering.Angiogenesis · 2014Review
- Digital subtraction angiography and computer assisted image analysis for the evaluation of the antiangiogenetic effect of ionizing radiation on tumor angiogenesis.International urology and nephrology · 2006Article
- Combined effects of radiotherapy and angiostatin gene therapy in glioma tumor model.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Effects of low dose ionizing radiation on murine chronic granulomatous tissue.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 1998Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have investigated both the effects of X-rays on angiogenesis and the possible role of nitric oxide (NO) on the observed antiangiogenic effect of X-rays, using as an in vivo model the chick embryo chorioallantoic membrane (CAM). These effects were assessed both morphologically and biochemically, by measuring vascular density and collagenous protein biosynthesis, respectively, on days 9 and 14 of the chick embryo development. Vascular density and cytotoxicity of the CAM were also evaluated histologically. We have shown that X-rays have an antiangiogenic effect on the system used and that the NO synthase inhibitor NG-nitro-L-arginine methyl ester (L-NAME) promoted angiogenesis of the non-irradiated CAM and reversed the antiangiogenic effect of irradiation. D-NAME, which is an inactive enantiomer of L-NAME, showed no such effects. L-Arginine, which is the substrate for NO synthase, had a modest antiangiogenic effect on the non-irradiated CAM, no effect on the irradiated CAM and abolished the angiogenic effect of L-NAME on these CAM preparations. These results suggest that NO is involved in the antiangiogenic mechanism of X-rays and that pharmacological manipulation of NO firstly, may offer a better understanding of these mechanisms and, secondly, may also prove to be an alternative therapeutic approach for treating pathological conditions involving angiogenesis.
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