ArticleThe Journal of cell biology1996
Cell adhesion molecules NgCAM and axonin-1 form heterodimers in the neuronal membrane and cooperate in neurite outgrowth promotion.
Article in The Journal of cell biology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 128 citations in OpenAlex.
- Molecular mechanism of contactin 2 homophilic interaction.Structure (London, England : 1993) · 2024Article
- L1 Syndrome Prenatal Diagnosis Supplemented by Functional Analysis of One L1CAM Gene Missense Variant.Reproductive sciences (Thousand Oaks, Calif.) · 2022Article
- Live imaging of retinotectal mapping reveals topographic map dynamics and a previously undescribed role for Contactin 2 in map sharpening.Development (Cambridge, England) · 2021Article
- Caspase-3 Cleaves Extracellular Vesicle Proteins During Auditory Brainstem Development.Frontiers in cellular neuroscience · 2020Article
- Distinct roles for the cell adhesion molecule Contactin2 in the development and function of neural circuits in zebrafish.Mechanisms of development · 2018Article
- Contactin-2/TAG-1, active on the front line for three decades.Cell adhesion & migration · 2017Article
- Glycosylphosphatidylinositol-Anchored Immunoglobulin Superfamily Cell Adhesion Molecules and Their Role in Neuronal Development and Synapse Regulation.Frontiers in molecular neuroscience · 2017Review
- Review
- Axonal transport plays a crucial role in mediating the axon-protective effects of NmNAT.Neurobiology of disease · 2014Article
- Molecular events in the cell types of the olfactory epithelium during adult neurogenesis.Molecular brain · 2013Article
- TAG1 regulates the endocytic trafficking and signaling of the semaphorin3A receptor complex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Article
- Clustering and activity tuning of Kv1 channels in myelinated hippocampal axons.The Journal of biological chemistry · 2011Article
- Contactins: structural aspects in relation to developmental functions in brain disease.Advances in protein chemistry and structural biology · 2011Review
- Lewis(x) and alpha2,3-sialyl glycans and their receptors TAG-1, Contactin, and L1 mediate CD24-dependent neurite outgrowth.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Effects of ethanol on axon outgrowth and branching in developing rat cortical neurons.Neuroscience · 2008Article
- Interactions between the L1 cell adhesion molecule and ezrin support traction-force generation and can be regulated by tyrosine phosphorylation.Journal of neuroscience research · 2008Article
- The SALM family of adhesion-like molecules forms heteromeric and homomeric complexes.The Journal of biological chemistry · 2008Article
- The crystal structure of the ligand-binding module of human TAG-1 suggests a new mode of homophilic interaction.Protein science : a publication of the Protein Society · 2007Article
- Alteration of the cell adhesion molecule L1 expression in a specific subset of primary afferent neurons contributes to neuropathic pain.The European journal of neuroscience · 2007Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The axonal surface glycoproteins neuronglia cell adhesion molecule (NgCAM) and axonin-1 promote cell-cell adhesion, neurite outgrowth and fasciculation, and are involved in growth cone guidance. A direct binding between NgCAM and axonin-1 has been demonstrated using isolated molecules conjugated to the surface of fluorescent microspheres. By expressing NgCAM and axonin-1 in myeloma cells and performing cell aggregation assays, we found that NgCAM and axonin-1 cannot bind when present on the surface of different cells. In contrast, the cocapping of axonin-1 upon antibody-induced capping of NgCAM on the surface of CV-1 cells coexpressing NgCAM and axonin-1 and the selective chemical cross-linking of the two molecules in low density cultures of dorsal root ganglia neurons indicated a specific and direct binding of axonin-1 and Ng-CAM in the plane of the same membrane. Suppression of the axonin-1 translation by antisense oligonucleotides prevented neurite outgrowth in dissociated dorsal root ganglia neurons cultured on an NgCAM substratum, indicating that neurite outgrowth on NgCAM substratum requires axonin-1. Based on these and previous results, which implicated NgCAM as the neuronal receptor involved in neurite outgrowth on NgCAM substratum, we concluded that neurite outgrowth on an NgCAM substratum depends on two essential interactions of growth cone NgCAM: a trans-interaction with substratum NgCAM and a cis-interaction with axonin-1 residing in the same growth cone membrane.
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