ArticleThe Journal of cell biology1996
Native chick laminin-4 containing the beta 2 chain (s-laminin) promotes motor axon growth.
Article in The Journal of cell biology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Heterogeneous fibroblasts contribute to fibrotic scar formation after spinal cord injury in mice and monkeys.Nature communications · 2024Article
- A novel laminin β gene BmLanB1-w regulates wing-specific cell adhesion in silkworm, Bombyx mori.Scientific reports · 2015Article
- Article
- Laminin-121--recombinant expression and interactions with integrins.Matrix biology : journal of the International Society for Matrix Biology · 2010Article
- Laminin chain assembly is regulated by specific coiled-coil interactions.Journal of structural biology · 2010Article
- A nonadjuvanted polypeptide nanoparticle vaccine confers long-lasting protection against rodent malaria.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- Incomplete nonsense-mediated decay of mutant lamin A/C mRNA provokes dilated cardiomyopathy and ventricular tachycardia.Journal of molecular medicine (Berlin, Germany) · 2008Article
- Bridging structure with function: structural, regulatory, and developmental role of laminins.The international journal of biochemistry & cell biology · 2008Review
- The Caenorhabditis elegans septin complex is nonpolar.The EMBO journal · 2007Article
- Functions and dysfunctions of the nuclear lamin Ig-fold domain in nuclear assembly, growth, and Emery-Dreifuss muscular dystrophy.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Structural insights into the EB1-APC interaction.The EMBO journal · 2005Article
- Structure and disorder in the ribonuclease S-peptide probed by NMR residual dipolar couplings.Protein science : a publication of the Protein Society · 2003Article
- Functional peptide sequences derived from extracellular matrix glycoproteins and their receptors: strategies to improve neuronal regeneration.Molecular neurobiology · 2003Review
- Expression of mutant Ets protein at the neuromuscular synapse causes alterations in morphology and gene expression.EMBO reports · 2002Article
- Op18/stathmin caps a kinked protofilament-like tubulin tetramer.The EMBO journal · 2000Article
- An autonomous folding unit mediates the assembly of two-stranded coiled coils.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Modulation of synapsin I gene expression in rat cortical neurons by extracellular matrix.Cellular and molecular neurobiology · 1998Article
- The role of laminins in basement membrane function.Journal of anatomy · 1998Review
- A distinct 14 residue site triggers coiled-coil formation in cortexillin I.The EMBO journal · 1998Article
- Distribution and function of laminins in the neuromuscular system of developing, adult, and mutant mice.The Journal of cell biology · 1997Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
After denervation of muscle, motor axons reinnervate original synaptic sites. A recombinant fragment of the synapse specific laminin beta 2 chain (s-laminin) was reported to inhibit motor axon growth. Consequently, a specific sequence (leucine-arginine-glutamate, LRE) of the laminin beta 2 chain was proposed to act as a stop signal and to mediate specific reinnervation at the neuromuscular junction (Porter, B.E., J. Weis, and J.R. Sanes. 1995. Neuron. 14:549-559). We demonstrate here that native chick laminin-4, which contains the beta 2 chain and is present in the synaptic basement membrane, does not inhibit but rather promotes motor axon growth. In native heterotrimeric laminin, the LRE sequence of the beta 2 chain is found in a triple coiled-coil region that is formed by all three subunits. We show here that the effect of LRE depends on the structural context. Whereas a recombinant randomly coiled LRE peptide indeed inhibited outgrowth by chick motoneurons, a small recombinant triple coiled-coil protein containing this sequence did not.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.