ArticleThe EMBO journal1996
Aggregation-dependent, integrin-mediated increases in cytoskeletally associated PtdInsP2 (4,5) levels in human platelets are controlled by translocation of PtdIns 4-P 5-kinase C to the cytoskeleton.
Article in The EMBO journal, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 63 citations in OpenAlex.
- Identification of ARUK2002821 as an isoform-selective PI5P4Kα inhibitor.RSC medicinal chemistry · 2023Article
- Signaling Enzymes and Ion Channels Being Modulated by the Actin Cytoskeleton at the Plasma Membrane.International journal of molecular sciences · 2021Review
- Differential SKIP expression in PTEN-deficient glioblastoma regulates cellular proliferation and migration.Oncogene · 2015Article
- PIPKIIα is widely expressed in hematopoietic-derived cells and may play a role in the expression of alpha- and gamma-globins in K562 cells.Molecular and cellular biochemistry · 2014Article
- A novel membrane-dependent on/off switch mechanism of talin FERM domain at sites of cell adhesion.Cell research · 2012Article
- A novel HPLC-based approach makes possible the spatial characterization of cellular PtdIns5P and other phosphoinositides.The Biochemical journal · 2010Article
- Phosphoinositide-specific phospholipase C in oat roots: association with the actin cytoskeleton.Planta · 2009Article
- An association screen of myelin-related genes implicates the chromosome 22q11 PIK4CA gene in schizophrenia.Molecular psychiatry · 2008Article
- Structural basis for the autoinhibition of talin in regulating integrin activation.Molecular cell · 2008Article
- Regulation of type II PIP kinase by PKD phosphorylation.Cellular signalling · 2006Article
- Supervised membrane swimming: small G-protein lifeguards regulate PIPK signalling and monitor intracellular PtdIns(4,5)P2 pools.The Biochemical journal · 2006Review
- Type IIalpha phosphatidylinositol phosphate kinase associates with the plasma membrane via interaction with type I isoforms.The Biochemical journal · 2002Article
- Plasma membrane phosphatidylinositol 4,5-bisphosphate levels decrease with time in culture.Plant physiology · 2001Article
- Nuclear targeting of the beta isoform of type II phosphatidylinositol phosphate kinase (phosphatidylinositol 5-phosphate 4-kinase) by its alpha-helix 7.The Biochemical journal · 2000Article
- Relocalization of phospholipase D activity mediates membrane formation during meiosis.The Journal of cell biology · 1998Article
- Regulation of PtdIns4P 5-kinase C by thrombin-stimulated changes in its phosphorylation state in human platelets.The Biochemical journal · 1998Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Thrombin-stimulated aggregation of human platelets promotes an increase in the phosphatidylinositol 4-phosphate (PtdIns 4-P) 5-kinase (PIPkin) activity in the cytoskeleton. This phenomenon is associated with translocation of PIPkin isoform C to the cytoskeleton and with an increase in the amount of phosphatidylinositol bisphosphate (PtdInsP2) bound to the cytoskeletal pellet. All three of these effects are prevented if the platelets are not stirred or if RGD-containing peptides are present, demonstrating that they require integrin activation. All three are also abolished by pretreatment with okadaic acid, which also prevents the aggregation-dependent translocation of pp60(c-src) to the cytoskeleton. The results point to the existence of a cytoskeletally associated PtdInsP2 pool under the control of integrin-mediated signals that act via PIPkin C and suggest that a common, okadaic acid-sensitive mechanism may underlie the aggregation-dependent translocation of certain signalling molecules to the platelet cytoskeleton.
Indexed as
Identifiers
8978678PMC452476W2289547287What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.