ArticleGenetics1996
Molecular dissection of a major gene effect on a quantitative trait: the level of alcohol dehydrogenase expression in Drosophila melanogaster.
Article in Genetics, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 1 of them a synthesis that pooled it.
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Who cites it
59 citing papers in PubMed, 1 synthesis or guideline pooled it.
- How species evolve collectively: implications of gene flow and selection for the spread of advantageous alleles.Molecular ecology · 2004Pooled it
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- Analysis of Epistasis in Natural Traits Using Model Organisms.Trends in genetics : TIG · 2018Review
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- The sources of adaptive variation.Proceedings. Biological sciences · 2017Review
- Experimental test and refutation of a classic case of molecular adaptation in Drosophila melanogaster.Nature ecology & evolution · 2017Article
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- Expression of tandem gene duplicates is often greater than twofold.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Intraspecific polymorphism, interspecific divergence, and the origins of function-altering mutations in deer mouse hemoglobin.Molecular biology and evolution · 2015Article
- Accounting for genetic architecture improves sequence based genomic prediction for a Drosophila fitness trait.PloS one · 2015Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A molecular mapping experiment shows that a major gene effect on a quantitative trait, the level of alcohol dehydrogenase expression in Drosophila melanogaster, is due to multiple polymorphisms within the Adh gene. These polymorphisms are located in an intron, the coding sequence, and the 3' untranslated region. Because of nonrandom associations among polymorphisms at different sites, the individual effects combine (in some cases epistatically) to produce "superalleles" with large effect. These results have implications for the interpretation of major gene effects detected by quantitative trait locus mapping methods. They show that large effects due to a single locus may be due to multiple associated polymorphisms (or sequential fixations in isolated populations) rather than individual mutations of large effect.
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