ArticleGenetics1996
Aspergillus fabM encodes an essential product that is related to poly(A)-binding proteins and activates development when overexpressed.
Article in Genetics, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 23 citations in OpenAlex.
- HJournal of fungi (Basel, Switzerland) · 2021Article
- Functions of PUF Family RNA-Binding Proteins inJournal of microbiology and biotechnology · 2021Article
- The Aspergillus nidulans Pbp1 homolog is required for normal sexual development and secondary metabolism.Fungal genetics and biology : FG & B · 2017Article
- The SrkA Kinase Is Part of the SakA Mitogen-Activated Protein Kinase Interactome and Regulates Stress Responses and Development in Aspergillus nidulans.Eukaryotic cell · 2015Article
- Fungal genes in context: genome architecture reflects regulatory complexity and function.Genome biology and evolution · 2013Article
- Four distinct classes of proteins as interaction partners of the PABC domain of Arabidopsis thaliana Poly(A)-binding proteins.Molecular genetics and genomics : MGG · 2005Article
- Evidence that poly(A) binding protein has an evolutionarily conserved function in facilitating mRNA biogenesis and export.RNA (New York, N.Y.) · 2003Article
- Article
- Poly(A)-binding protein I of Leishmania: functional analysis and localisation in trypanosomatid parasites.Nucleic acids research · 2000Article
- Asexual sporulation in Aspergillus nidulans.Microbiology and molecular biology reviews : MMBR · 1998Review
- HOY1, a homeo gene required for hyphal formation in Yarrowia lipolytica.Molecular and cellular biology · 1997Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Overexpression of several different Aspergillus nidulans developmental regulatory genes has been shown to cause inappropriate developmental activation and growth inhibition. We previously exploited this observation that induced development caused growth inhibition in designing a screen to identify other genes that could activate development when overexpressed. We identified 16 mutants in which induced expression of different random genomic DNA sequences caused growth inhibition, accumulation of mRNA corresponding to the brlA developmental regulatory locus, and in several cases sporulation. This phenotype was designated FAB for Forced expression Activation of brlA and the genes were called fabA through fabP. Here we describe one of these genes, fabM, which is predicted to encode a poly(A)-binding protein (PABP) that is constitutively expressed and is essential for viability. While it is unclear why overexpression of the fabM caused sporulation, we showed that this activity required other known early developmental regulators including brlA beta, flbA, flbB, flbC, and fluG. We propose that fabM is an example of a gene that is not only required for growth, but also has specific functions early in development that assist, developmental induction, presumably by allowing translation of specific mRNAs like brlA.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.