Evidence map›Paper›PMID 8978026›Full record

ArticleGenetics1996

Dosage suppressors of a benomyl-dependent tubulin mutant: evidence for a link between microtubule stability and cellular metabolism.

N A Machin, J M Lee, K Chamany, G Barnes

Abstract read
In one paragraph

Article in Genetics, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 96% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

N A MachinDepartment of Molecular and Cell Biology, University of California, Berkeley, USA.
J M Lee
K Chamany
G Barnes
University of California, Berkeley · US

Funding

SACCHAROMYCES CEREVISIAE MICROTUBULE CYTOSKELETONR01GM047842 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI BARNES, GEORJANA · 1993 to 2022
$7.5M
SACCHAROMYCES CEREVISIAE MICROTUBULE CYTOSKELETONR55GM047842 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI BARNES, GEORJANA · 1992 to 1992
–
NIGMS NIH HHS GM-47842
6 · The paper itself

Abstract

To identify factors important for the regulation of microtubule stability in yeast, dosage suppressors of the hyperstable microtubule phenotype of the budding yeast tub2-150 beta-tubulin mutation were isolated. Of the two suppressors reported here, one (JSN2) encodes a tRNAVal, and the other (JSN3) is an antimorphic allele of the methionine biosynthesis transcription factor Met4p. Furthermore, growth of tub2-150 mutants and suppression of tub2-150 mutants by JSN3 are sensitive to levels of methionine in the growth medium. We explore several possible explanations for these findings, including the potential involvement of the general amino acid control and the involvement of Cbflp, a component of yeast kinetochores that is also necessary for Met4p-mediated transcription.

Indexed as

Genes, FungalGenes, SuppressorAmino Acid SequenceBase SequenceBenomylGene Expression Regulation, FungalMicrotubulesMolecular Sequence DataMutationSaccharomyces cerevisiaeTubulinBenomylTubulin

Identifiers

PMID8978026
PMCPMC1207690
OpenAlexW1922440338

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.