ArticleGut1996
Proteolytic degradation of intestinal mucosal extracellular matrix after lamina propria T cell activation.
Article in Gut, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 54 citations in OpenAlex.
- Towards Full Thickness Small Intestinal Models: Incorporation of Stromal Cells.Tissue engineering and regenerative medicine · 2024Review
- Review
- Correlation of MMP-3 and MMP-9 with Crohn's disease activity in children.Digestive diseases and sciences · 2012Article
- The role of NF-kappaB, IRF-1, and STAT-1alpha transcription factors in the iNOS gene induction by gliadin and IFN-gamma in RAW 264.7 macrophages.Journal of molecular medicine (Berlin, Germany) · 2006Article
- Expression of matrix metalloproteinases and tissue inhibitor metalloproteinases increases in X-irradiated rat ileum despite the disappearance of CD8a T cells.World journal of gastroenterology · 2005Article
- Biochemical and immunohistochemical analysis of glycosaminoglycans in inflamed and non-inflamed intestinal mucosa of patients with Crohn's disease.International journal of colorectal disease · 2005Article
- Epithelial expression and release of FGF-2 from heparan sulphate binding sites in bronchial tissue in asthma.Thorax · 2004Article
- Gliadin increases iNOS gene expression in interferon-gamma-stimulated RAW 264.7 cells through a mechanism involving NF-kappa B.Naunyn-Schmiedeberg's archives of pharmacology · 2003Article
- Impaired rejection and mucosal injury of small intestinal allografts lacking the interferon-gamma receptor.International journal of experimental pathology · 2003Article
- Article
- Article
- The role of up-regulated serine proteases and matrix metalloproteinases in the pathogenesis of a murine model of colitis.The American journal of pathology · 2000Article
- Article
- Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundProteoglycans, consisting of glycosaminoglycan (GAG) side chains covalently linked to a protein core, are a major component of the extracellular matrix of the intestinal lamina propria.
aimsThis study investigated the effects of lamina propria T cell activation on the proteoglycan component of the matrix.
methodsThe high degree of sulphation of GAGs means that they are polyanionic and thus can be visualised in tissue sections by means of colloidal-gold labelled cationic probes.
resultsIn human fetal small intestine there is a dense meshwork of anionic residues in the lamina propria and basement membrane. When explants of human fetal small intestine are cultured ex vivo, and resident lamina propria T cells are activated with pokeweed mitogen, mucosal destruction occurs within three days. This is associated with the rapid loss of anionic sites from the lamina propria. Dermatan sulphate proteoglycan is lost from the tissue and is present at increased concentrations in the organ culture supernatants, indicating that T cell activation has led to solubilisation of lamina propria proteoglycans. Tissue destruction and loss of anionic residues are inhibited in a dose dependent fashion by dexamethasone, and by the protease inhibitor, alpha 2 macroglobulin.
conclusionsProteolytic degradation of the lamina propria may therefore be a mechanism by which T cell hypersensitivity injures the intestinal mucosa.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.