ArticleGut1996
Gastrointestinal hormones in short bowel syndrome. Peptide YY may be the 'colonic brake' to gastric emptying.
Article in Gut, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
48 citing papers in PubMed, 1 synthesis or guideline pooled it, 184 citations in OpenAlex.
- Guideline
- Regional organization of nutrient absorption across the small intestine.Nature reviews. Gastroenterology & hepatology · 2026Review
- Molecular Mechanisms of Intestinal Adaptation in Short Bowel Syndrome: A Comprehensive Review.International journal of molecular sciences · 2026Review
- Uncovering differences in rye and wheat degradation by human gut microbiota applying a quantitative multi-metaOmicsCurrent research in microbial sciences · 2026Article
- Paracrine relationship between incretin hormones and endogenous 5-hydroxytryptamine in the small and large intestine.Neurogastroenterology and motility · 2023Article
- The Role of a Colon-in-Continuity in Short Bowel Syndrome.Nutrients · 2023Review
- Concise review on short bowel syndrome: Etiology, pathophysiology, and management.World journal of clinical cases · 2022Review
- Review
- How to manage a high-output stoma.Frontline gastroenterology · 2022Article
- Small and Large Intestine (II): Inflammatory Bowel Disease, Short Bowel Syndrome, and Malignant Tumors of the Digestive Tract.Nutrients · 2021Review
- Sitagliptin, a dipeptidyl peptidase-4 inhibitor, in patients with short bowel syndrome and colon in continuity: an open-label pilot study.BMJ open gastroenterology · 2021Article
- Nutritional and pharmacological strategy in children with short bowel syndrome.Pediatric surgery international · 2021Review
- Assessment of Risk Factors for the Occurrence of a High-Output Ileostomy.Frontiers in surgery · 2021Article
- Carbohydrates designed with different digestion rates modulate gastric emptying response in rats.International journal of food sciences and nutrition · 2020Article
- The effect of probiotics on ıntestinal motility in an experimental short bowel model.Acta cirurgica brasileira · 2020Article
- Efficacy of teduglutide in a patient with Crohn's disease and short bowel syndrome on enteral nutrition: let's start to think out of the box.Gastroenterology report · 2019Article
- The Long Road to the Development of Effective Therapies for the Short Gut Syndrome: A Personal Perspective.Digestive diseases and sciences · 2019Review
- Distal Bowel Re-feeding in Patients with Proximal Jejunostomy.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2018Article
- Parenteral Nutrition and Intestinal Failure.Nutrients · 2017Review
- Factors affecting poor nutritional status after small bowel resection in patients with Crohn disease.Medicine · 2016Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundShort bowel patients with a jejunostomy have large volume stomal outputs, which may in part be due to rapid gastric emptying of liquid. Short bowel patients with a preserved colon do not have such a high stool output and gastric emptying of liquid is normal.
aimsTo determine if differences in the gastric emptying rate between short bowel patients with and without a colon can be related to gastrointestinal hormone changes after a meal. SUBJECTS: Seven short bowel patients with no remaining colon (jejunal length 30-160 cm) and six with jejunum in continuity with a colon (jejunal length 25-75 cm), and 12 normal subjects.
methodsThe subjects all consumed a 640 kcal meal; blood samples were taken for 180 minutes for measurement of gastrointestinal hormones.
resultsPatients with a colon had high fasting peptide YY values (median 71 pmol/l with a colon; 11 pmol/l normal subjects, p < 0.005) with a normal postprandial rise, but those without a colon had a low fasting (median 7 pmol/l, p = 0.076) and a reduced postprandial peptide YY response (p < 0.050). Motilin values were high in some patients without a colon. In both patient groups fasting and postprandial gastrin and cholecystokinin values were high while neurotensin values were low. There were no differences between patient groups and normal subjects in enteroglucagon, pancreatic polypeptide, or somatostatin values.
conclusionsLow peptide YY values in short bowel patients without a colon may cause rapid gastric emptying of liquid. High values of peptide YY in short bowel patients with a retained colon may slow gastric emptying of liquid and contribute to the "colonic brake'.
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