ArticleArchives of disease in childhood. Fetal and neonatal edition1996
Hypoxic-ischaemic encephalopathy: early and late magnetic resonance imaging findings in relation to outcome.
Article in Archives of disease in childhood. Fetal and neonatal edition, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
62 citing papers in PubMed, 1 synthesis or guideline pooled it.
- MRI scoring systems in neonatal encephalopathy and neurodevelopmental outcomes: a systematic review.Journal of perinatology : official journal of the California Perinatal Association · 2026Pooled it
- Therapeutic hypothermia for neonatal encephalopathy results in improved microstructure and metabolism in the deep gray nuclei.AJNR. American journal of neuroradiology · 2012Trial
- The TOBY Study. Whole body hypothermia for the treatment of perinatal asphyxial encephalopathy: a randomised controlled trial.BMC pediatrics · 2008Trial
- Bridging the gap: Translating fetal, infant, and toddler neuroimaging insights into clinical practice.Developmental cognitive neuroscience · 2026Review
- Hypoxic Ischemic Encephalopathy: Hearing Impairment and Related Risk Factors.Journal of clinical medicine · 2026Article
- Neonatal and Two-Year Prognosis of Eutrophic Newborns from Monochorionic Diamniotic Twin Pregnancies Complicated by Selective Intrauterine Growth Restriction.Children (Basel, Switzerland) · 2025Article
- Therapeutic Hypothermia and Its Role in Preserving Brain Volume in Term Neonates with Perinatal Asphyxia.Journal of clinical medicine · 2024Article
- Insights from serial magnetic resonance imaging in neonatal encephalopathy in term infants.Pediatric research · 2024Article
- Volumetric apparent diffusion coefficient histogram analysis in term neonatal asphyxia treated with hypothermia.The British journal of radiology · 2024Article
- Cranial MRI beyond the Neonatal Period and Neurodevelopmental Outcomes in Neonatal Encephalopathy Due to Perinatal Asphyxia: A Systematic Review.Journal of clinical medicine · 2023Review
- Differences between early and late MRI in infants with neonatal encephalopathy following therapeutic hypothermia.Pediatric research · 2023Article
- Correlation of Different MRI Scoring Systems with Long-Term Cognitive Outcome in Cooled Asphyxiated Newborns.Children (Basel, Switzerland) · 2023Article
- Brain volumes and functional outcomes in children without cerebral palsy after therapeutic hypothermia for neonatal hypoxic-ischaemic encephalopathy.Developmental medicine and child neurology · 2023Article
- Fidelity of 3D Printed Brains from MRI Scan in Children with Pathology (Prior Hypoxic Ischemic Injury).Journal of digital imaging · 2023Article
- pCO2 values in asphyxiated infants under therapeutic hypothermia after tailored respiratory management: a retrospective cohort study.Frontiers in pediatrics · 2023Article
- Research progress of neonatal hypoxic-ischemic encephalopathy in nonhuman primate models.Ibrain · 2023Review
- Magnetic Resonance Imaging Evaluation of Perinatal Hypoxic Ischemic Encephalopathy: An Institutional Experience.Journal of neurosciences in rural practice · 2022Article
- Validity of SyMRI for Assessment of the Neonatal Brain.Clinical neuroradiology · 2021Article
- MRI Score Ability to Detect Abnormalities in Mild Hypoxic-Ischemic Encephalopathy.Pediatric neurology · 2021Article
- Impact of Prematurity on the Tissue Properties of the Neonatal Brain Stem: A Quantitative MR Approach.AJNR. American journal of neuroradiology · 2021Article
2 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sixteen infants with hypoxic-ischaemic encephalopathy (HIE) were studied using serial magnetic resonance imaging (MRI) up to the age of 2 years. The infants had regular neurological and developmental assessments. An nuclear magnetic resonance (NMR) score was devised to quantify the early and late MRI findings and a neurological optimality score was used to quantify abnormal neurological signs at the time of the final examination. The follow up MRI score was compared with the neonatal MRI score and the outcome of the child. There was a strong positive correlation between the neonatal and follow up MRI scores and between MRI scores and optimality score. All infants with a normal outcome had patchy white matter abnormalities. All infants with an abnormal outcome had extensive white matter abnormalities. The outcome was most severe in those infants with additional basal ganglia atrophy with or without cyst formation. Infants with mild HIE who are developmentally normal at the age of 2 years do not have normal MRI scans and may be at risk of minor neurological problems by school age. Bilateral basal ganglia abnormalities are associated with severe developmental delay, but infants with mainly white matter and cortical abnormalities have less severe problems despite extensive tissue loss.
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