ArticleAnnals of the rheumatic diseases1996
Thrombin receptor expression in rheumatoid and osteoarthritic synovial tissue.
Article in Annals of the rheumatic diseases, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 34 citations in OpenAlex.
- Article
- Protease Activated Receptors and Arthritis.International journal of molecular sciences · 2021Review
- Targeting Proteinase Activated Receptor-4 Reduces Mechanonociception During the Acute Inflammatory Phase but not the Chronic Neuropathic Phase of Osteoarthritis in Rats.Frontiers in pharmacology · 2021Article
- Proteinases and their receptors in inflammatory arthritis: an overview.Nature reviews. Rheumatology · 2018Review
- Small GTP-binding protein Rho-mediated signaling promotes proliferation of rheumatoid synovial fibroblasts.Arthritis research & therapy · 2005Article
- Amelioration of collagen-induced arthritis by thrombin inhibition.The Journal of clinical investigation · 2001Article
- Effect of thrombin inhibition on synovial inflammation in antigen induced arthritis.Annals of the rheumatic diseases · 2000Article
- Enhanced expression of genes involved in coagulation and fibrinolysis in murine arthritis.Arthritis research · 2000Article
- Thrombin receptor mediated signals induce expressions of interleukin 6 and granulocyte colony stimulating factor via NF-kappa B activation in synovial fibroblasts.Annals of the rheumatic diseases · 1999Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo investigate the possibility that synovial cells might respond to thrombin in the inflamed human joint, using immunohistochemical detection of thrombin receptors.
methodsFrozen sections of synovial membrane from 20 patients with rheumatoid arthritis, 16 with osteoarthritis, and four normal controls were stained using a monoclonal antibody to the human thrombin receptor. Sections were also double stained for both receptors and non-specific esterase.
resultsReceptor positive cells were present in rheumatoid synovia, with some cells also staining positively for non-specific esterase. In contrast, both osteoarthritic and normal synovia contained very few cells expressing receptors.
conclusionsThrombin may mediate important pathological changes during chronic inflammatory joint disease.
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