ArticleThe Journal of experimental medicine1996
Antineutrophil cytoplasmic autoantibodies interact with primary granule constituents on the surface of apoptotic neutrophils in the absence of neutrophil priming.
Article in The Journal of experimental medicine, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed, 147 citations in OpenAlex.
- Impact of lymphocyte transformation test on the diagnostic accuracy of the culprit drug in drug-induced cytopenias: a case-control study.Frontiers in pharmacology · 2025Article
- Mechanisms of vascular damage in ANCA vasculitis.Seminars in immunopathology · 2022Review
- Development of Myeloperoxidase Anti-neutrophil Cytoplasmic Antibody-positive Necrotizing Crescentic Glomerulonephritis in an Elderly Patient with Immunological Kidney Disease.Internal medicine (Tokyo, Japan) · 2021Article
- Drug-Induced Idiosyncratic Agranulocytosis - Infrequent but Dangerous.Frontiers in pharmacology · 2021Review
- Autoantibody Biomarkers in Rheumatic Diseases.International journal of molecular sciences · 2020Review
- Biomarkers in Vasculitides of the Nervous System.Frontiers in neurology · 2019Review
- Extranodal NK/T-cell Lymphoma, Nasal Type Accompanied by PR3-ANCA-associated Glomerulonephritis.Internal medicine (Tokyo, Japan) · 2017Article
- Article
- Towards a four-dimensional view of neutrophils.Methods in molecular biology (Clifton, N.J.) · 2012Review
- Antineutrophil cytoplasmic antibodies, autoimmune neutropenia, and vasculitis.Seminars in arthritis and rheumatism · 2011Article
- ANCA-associated vasculitides--advances in pathogenesis and treatment.Nature reviews. Rheumatology · 2010Review
- Anti-neutrophil cytoplasmic antibody pathogenesis in small-vessel vasculitis: an update.The American journal of pathology · 2009Review
- Wegener's granulomatosis: the current view.Clinical reviews in allergy & immunology · 2008Review
- Pathways to ANCA production: from differentiation of dendritic cells by proteinase 3 to B lymphocyte maturation in Wegener's granuloma.Clinical reviews in allergy & immunology · 2008Review
- Neutrophil surface presentation of the anti-neutrophil cytoplasmic antibody-antigen proteinase 3 depends on N-terminal processing.Clinical and experimental immunology · 2008Article
- Neutrophil apoptosis in autoimmunity.Journal of molecular medicine (Berlin, Germany) · 2006Review
- Serum level of sFas in patients with Wegener's granulomatosis.Clinical rheumatology · 2006Article
- Current state of tumour necrosis factor {alpha} blockade in Wegener's granulomatosis.Annals of the rheumatic diseases · 2005Review
- Antineutrophil cytoplasmic antibody (ANCA)-associated autoimmune diseases induced by antithyroid drugs: comparison with idiopathic ANCA vasculitides.Arthritis research & therapy · 2005Article
- Dendritic cells overexpressing Fas-ligand induce pulmonary vasculitis in mice.Clinical and experimental immunology · 2004Article
Corrections and comments
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Authors and funding
10 authors at 6 institutions in 3 countries.
Funding
Abstract
The pathogenic role of antineutrophil cytoplasmic autoantibodies (ANCA) remains controversial because of the difficulty in explaining how extracellular ANCA can interact with intracellular primary granule constituents. It has been postulated that cytokine priming of neutrophils (PMN), as may occur during a prodromal infection, is an important trigger for mobilization of granules to the cell surface, where they may interact with ANCA. We show by electron microscopy that apoptosis of unprimed PMN is also associated with the translocation of cytoplasmic granules to the cell surface and alignment just beneath an intact cell membrane. Immunofluorescent microscopy and FACS analysis demonstrate reactivity of ANCA-positive sera and antimyeloperoxidase antibodies with apoptotic PMN, but not with viable PMN. Moreover, we show that apoptotic PMN may be divided into two subsets, based on the presence or absence of granular translocation, and that surface immunogold labeling of myeloperoxidase occurs only in the subset of PMN showing translocation. These results provide a novel mechanism that is independent of priming, by which ANCA may gain access to PMN granule components during ANCA-associated vasculitis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.