ArticleInfection and immunity1997
Identification of a family of intimins common to Escherichia coli causing attaching-effacing lesions in rabbits, humans, and swine.
Article in Infection and immunity, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 79 citations in OpenAlex.
- Overexpressed Palladin Rescues Enteropathogenic E. coli (EPEC) Pedestal Lengths in ArpC2 Depleted Cells.Cytoskeleton (Hoboken, N.J.) · 2025Article
- Cloning approach and functional analysis of anti-intimin single-chain variable fragment (scFv).BMC research notes · 2011Article
- Enhanced Actin Pedestal Formation by Enterohemorrhagic Escherichia coli O157:H7 Adapted to the Mammalian Host.Frontiers in microbiology · 2011Article
- Virulence mechanisms of Tannerella forsythia.Periodontology 2000 · 2010Review
- Genes related to long polar fimbriae of pathogenic Escherichia coli strains as reliable markers to identify virulent isolates.Journal of clinical microbiology · 2009Article
- Intimin types determined by heteroduplex mobility assay of intimin gene (eae)-positive Escherichia coli strains.Journal of clinical microbiology · 2007Article
- Protection against hemorrhagic colitis in an animal model by oral immunization with isogeneic rabbit enteropathogenic Escherichia coli attenuated by truncating intimin.Infection and immunity · 2005Article
- Adherence of diarrheagenic Escherichia coli strains to epithelial cells.Infection and immunity · 2005Review
- Virulence of enteropathogenic Escherichia coli, a global pathogen.Clinical microbiology reviews · 2003Review
- Essential role for verotoxin in sustained stress-activated protein kinase and nuclear factor kappa B signaling, stimulated by Escherichia coli O157:H7 in Vero cells.Infection and immunity · 2002Article
- Genetic profiling of enterohemorrhagic Escherichia coli strains in relation to clonality and clinical signs of infection.Journal of clinical microbiology · 2002Article
- Locus of enterocyte effacement from Citrobacter rodentium: sequence analysis and evidence for horizontal transfer among attaching and effacing pathogens.Infection and immunity · 2001Article
- Complete nucleotide sequence and analysis of the locus of enterocyte Effacement from rabbit diarrheagenic Escherichia coli RDEC-1.Infection and immunity · 2001Article
- Identification of enteropathogenic Escherichia coli in simian immunodeficiency virus-infected infant and adult rhesus macaques.Journal of clinical microbiology · 2001Article
- Subtypes of intimin among non-toxigenic Escherichia coli from diarrheic calves in Brazil.Canadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2000Article
- Typing of intimin genes in human and animal enterohemorrhagic and enteropathogenic Escherichia coli: characterization of a new intimin variant.Infection and immunity · 2000Article
- Decreased adherence of enterohemorrhagic Escherichia coli to HEp-2 cells in the presence of antibodies that recognize the C-terminal region of intimin.Infection and immunity · 1999Article
- Identification of immunodominant regions within the C-terminal cell binding domain of intimin alpha and intimin beta from enteropathogenic Escherichia coli.Infection and immunity · 1998Article
- Molecular evolution of a pathogenicity island from enterohemorrhagic Escherichia coli O157:H7.Infection and immunity · 1998Article
- Direct detection of eae-positive bacteria in human and veterinary colorectal specimens by PCR.Journal of clinical microbiology · 1998Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intimin, an outer membrane protein encoded by eaeA that mediates close attachment of enteropathogenic bacteria to apical surfaces of epithelial cells, is required for formation of the attaching-effacing lesions and for full pathogenesis of the bacteria. Analysis of the eaeA sequence indicates that there is a high degree of homology at the N termini but less at the C termini of intimins. Antisera specific for the C-terminal third of RDEC-1 intimin, used to screen outer membrane proteins from 50 rabbit enteropathogenic Escherichia coli (EPEC), human EPEC, and human enterohemorrhagic E. coli (EHEC) strains, identified cross-reactive intimins from 24 isolates. Sequence analysis of the eaeA genes from human EPEC O111 and EHEC O26 isolates indicates that their intimins have C termini nearly identical to that of RDEC-1 intimin. Our results suggest that there are at least three families of related intimins and that the presence of intimin similar to that of RDEC-1 is not restricted by serogroup or host specificity.
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