ArticleInfection and immunity1997
Role of fimbriae in Porphyromonas gingivalis invasion of gingival epithelial cells.
Article in Infection and immunity, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 97 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
97 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review of the impact of Porphyromonas gingivalis on foam cell formation: Implications for the role of periodontitis in atherosclerosis.BMC oral health · 2023Pooled it
- Article
- Local and Systemic Effects ofMicroorganisms · 2023Review
- Virulence Factors of the Periodontal Pathogens: Tools to Evade the Host Immune Response and Promote Carcinogenesis.Microorganisms · 2023Review
- Influences of race/ethnicity in periodontal treatment response and bacterial distribution, a cohort pilot study.Frontiers in oral health · 2023Article
- Selective activation of TGFβ signaling byAmerican journal of cancer research · 2023Article
- Atypical cyclic di-AMP signaling is essential for Porphyromonas gingivalis growth and regulation of cell envelope homeostasis and virulence.NPJ biofilms and microbiomes · 2022Article
- Host and bacterial factors linking periodontitis and rheumatoid arthritis.Frontiers in immunology · 2022Review
- Porphyromonas gingivalis infection exacerbates oesophageal cancer and promotes resistance to neoadjuvant chemotherapy.British journal of cancer · 2021Article
- Gemella haemolysans inhibits the growth of the periodontal pathogen Porphyromonas gingivalis.Scientific reports · 2021Article
- Metabolic plasticity enables lifestyle transitions of Porphyromonas gingivalis.NPJ biofilms and microbiomes · 2021Article
- A bacterial tyrosine phosphatase modulates cell proliferation through targeting RGCC.PLoS pathogens · 2021Article
- Porphyromonas gingivalis gingipains potentially affect MUC5AC gene expression and protein levels in respiratory epithelial cells.FEBS open bio · 2021Article
- Probiotics alter biofilm formation and the transcription ofJournal of oral microbiology · 2020Article
- IntracellularFrontiers in cellular and infection microbiology · 2020Article
- Peptide-Based Inhibitors of Fimbrial Biogenesis in Porphyromonas gingivalis.Infection and immunity · 2019Article
- Citrullination mediated by PPAD constrains biofilm formation in P. gingivalis strain 381.NPJ biofilms and microbiomes · 2019Article
- The potential role ofInfectious agents and cancer · 2019Review
- Variability in Genomic and Virulent Properties ofFrontiers in cellular and infection microbiology · 2019Article
- Characterization and development of SAPP as a specific peptidic inhibitor that targets Porphyromonas gingivalis.Molecular oral microbiology · 2018Article
37 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Porphyromonas gingivalis is a periodontal pathogen capable of invading primary cultures of normal human gingival epithelial cells (NHGEC). Involvement of P. gingivalis fimbriae in the invasion process was examined. Purified P. gingivalis 33277 fimbriae blocked invasion of this organism into NHGEC in a dose-dependent manner. DPG3, a P. gingivalis fimbria-deficient mutant, was impaired in its invasion capability approximately eightfold compared to its parent, strain 381. However, adherence of the mutant was only 50% reduced compared to the parent. Biotin labeling of NHGEC surface proteins revealed that two fimbriated strains, but not DPG3, bound a 48-kDa NHGEC protein. Adhesin-receptor interactions, such as fimbriae binding to a 48-kDa NHGEC surface receptor, may trigger activation of eukaryotic proteins involved in signal transduction and/or provoke the generation of surface P. gingivalis molecules required for internalization.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.