ArticleMolecular and cellular biochemistry1996
Lipid metabolism in rats bearing the Yoshida AH-130 ascites hepatoma.
Article in Molecular and cellular biochemistry, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Cancer cachexia: multilevel metabolic dysfunction.Nature metabolism · 2024Review
- Abnormal lipid metabolism in cancer-associated cachexia and potential therapy strategy.Frontiers in oncology · 2023Review
- Energy metabolism in cachexia.EMBO reports · 2019Review
- Chemotherapy diminishes lipid storage capacity of adipose tissue in a preclinical model of colon cancer.Lipids in health and disease · 2017 · on this mapArticle
- Cachexia: a problem of energetic inefficiency.Journal of cachexia, sarcopenia and muscle · 2014Article
- Evidence and mechanisms of fat depletion in cancer.Nutrients · 2014Review
- A role of active brown adipose tissue in cancer cachexia?Oncology reviews · 2012Review
Corrections and comments
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Authors and funding
3 authors.
Funding
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Abstract
Rats bearing the Yoshida AH-130 ascites hepatoma showed important changes in lipid metabolism. The presence of this rapidly growing tumour induced a significant reduction in the intestinal absorption of an oral [14C]triolein load but without changes in whole body oxidation of the tracer to CO2. Both white (WAT) and brown (BAT) adipose tissue lipoprotein lipase (LPL) activities were increased at day 4 of tumour growth, changes that seem to be related with those observed in [14C]lipid accumulation; however, heart LPL activity was increased at day 7 but there was no change at day 4. In addition, there was a marked hyperlipemia in the tumour-bearing animals, whereas the blood ketone body concentrations were lower in these animals in comparison with the corresponding pair-fed group. The in vivo lipogenic rate was increased in liver of the tumour-bearing animals (day 4); conversely, it was decreased in WAT and skeletal muscle (day 4) and IBAT (day 7) of the AH-130-bearing rats. It may be suggested that the increased liver lipogenic rate associated with tumour burden is the main factor contributing to the hyperlipidaemia present in the Yoshida AH-130 bearing rats.
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