ArticleArchives of virology1996
Apoptosis and CD8-down-regulation in the thymus of chickens infected with Marek's disease virus.
Article in Archives of virology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- TNFRSF11B modulates Marek's disease virus infection by regulating apoptosis in chicken embryo fibroblasts.Frontiers in veterinary science · 2026Article
- Two distinct polymorphisms in the basic region of Meq protein of marek's disease virus alter pathological progression and clinical manifestations.Virology journal · 2025Article
- Amino acid insertion in the Meq protein of Marek's disease virus, an avian oncogenic herpesvirus, accelerates tumorigenesis.Microbiology spectrum · 2025Article
- Article
- Programmed Cell Death-1 Expression in T-Cell Subsets in Chickens Infected with Marek's Disease Virus.Pathogens (Basel, Switzerland) · 2025Article
- Article
- Marek's disease virus prolongs survival of primary chicken B-cells by inducing a senescence-like phenotype.PLoS pathogens · 2021Article
- Adiponectin and its receptor genes' expression in response to Marek's disease virus infection of White Leghorns.Poultry science · 2020Article
- Virus-induced immunosuppression in turkeys (Open veterinary journal · 2020Review
- Atrophy of primary lymphoid organs induced by Marek's disease virus during early infection is associated with increased apoptosis, inhibition of cell proliferation and a severe B-lymphopenia.Veterinary research · 2018Article
- The CD8α gene in duck (Anatidae): cloning, characterization, and expression during viral infection.Molecular biology reports · 2015Article
- Marek's disease virus may interfere with T cell immunity by TLR3 signals.Veterinary research communications · 2014Article
- Analysis of protein expression profiles in the thymus of chickens infected with Marek's disease virus.Virology journal · 2012Article
- Marek's disease virus infection induces widespread differential chromatin marks in inbred chicken lines.BMC genomics · 2012Article
- Molecular characterization of immunoinhibitory factors PD-1/PD-L1 in chickens infected with Marek's disease virus.Virology journal · 2012Article
- DNA Methylation Fluctuation Induced by Virus Infection Differs between MD-resistant and -susceptible Chickens.Frontiers in genetics · 2012Article
- Systems analysis of immune responses in Marek's disease virus-infected chickens identifies a gene involved in susceptibility and highlights a possible novel pathogenicity mechanism.Journal of virology · 2011Article
- Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Marek's disease virus (MDV)-infected chickens show thymic atrophy during the acute phase of infection. We examined whether the thymic atrophy by MDV-infection was mediated by apoptosis. Apoptosis-specific DNA ladderings were clearly observed in thymocytes one week after MDV-infection. Histological and flow cytometry studies revealed that immature CD4+ CD8+ thymocytes underwent apototic cell death. In addition, the expression level of CD8 molecules on both CD4(-)CD8+ and CD4+ CD8+ thymocyte populations was down-regulated in the infected chickens. These thymic changes might be involved in the pathogenesis of Marek's disease.
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