ArticleNucleic acids research1996
Molecular haplotyping of genetic markers 10 kb apart by allele-specific long-range PCR.
Article in Nucleic acids research, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed.
- Family-Based Haplotype Estimation and Allele Dosage Correction for Polyploids Using Short Sequence Reads.Frontiers in genetics · 2019Article
- Recent Advances in Experimental Whole Genome Haplotyping Methods.International journal of molecular sciences · 2017Review
- Haplotype-Contained PCR Products Analysis by Sequencing with Selective Restriction of Primer Extension.BioMed research international · 2017Article
- A hidden Markov model for haplotype inference for present-absent data of clustered genes using identified haplotypes and haplotype patterns.Frontiers in genetics · 2014Article
- Intraspecific evolution of human RCCX copy number variation traced by haplotypes of the CYP21A2 gene.Genome biology and evolution · 2013Article
- Determination of haplotypes at structurally complex regions using emulsion haplotype fusion PCR.BMC genomics · 2012Article
- Genetic Diversity and Balancing Selection within the Human Phenylalanine Hydroxylase (PAH) Gene Region in Iranian Population.Iranian journal of public health · 2012Article
- BanI/D13S141/D13S175 represents a novel informative haplotype at the GJB2 gene region in the Iranian population.Cellular and molecular neurobiology · 2011Article
- Whole-genome molecular haplotyping of single cells.Nature biotechnology · 2011Article
- A Simple PCR-RFLP Method for Genetic Phase Determination in Compound Heterozygotes.Frontiers in genetics · 2011Article
- High-throughput haplotype determination over long distances by haplotype fusion PCR and ligation haplotyping.Nature protocols · 2009Article
- Long-range, high-throughput haplotype determination via haplotype-fusion PCR and ligation haplotyping.Nucleic acids research · 2008Article
- An efficient method for multi-locus molecular haplotyping.Nucleic acids research · 2007Article
- The value of molecular haplotypes in a family-based linkage study.American journal of human genetics · 2006Article
- Shotgun haplotyping: a novel method for surveying allelic sequence variation.Nucleic acids research · 2005Article
- Direct molecular haplotyping by melting curve analysis of hybridization probes: beta 2-adrenergic receptor haplotypes as an example.Nucleic acids research · 2005Article
- A comprehensive literature review of haplotyping software and methods for use with unrelated individuals.Human genomics · 2005Review
- Molecular haplotyping by linking emulsion PCR: analysis of paraoxonase 1 haplotypes and phenotypes.Nucleic acids research · 2005Article
- Article
- Haplotype frequency estimation error analysis in the presence of missing genotype data.BMC bioinformatics · 2004Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Haplotypes, combinations of polymorphic markers in a chromosome, are critical for genome diversity research. However, their utility in population samplings is compromised by uncertain linkage phase determinations from unrelated individuals. Molecular haplotyping accomplishes direct phase determination by generation of hemizygous templates from diploid genomic samples. We report molecular haplotyping by allele-specific long-range PCR of two markers 9.5 kb apart at the CD4 locus: a bi-allelic Alu deletion and a multi-allelic repeat. We verified CD4 molecular haplotypes by classical Mendelian analysis. Molecular haplotyping should prove useful in mapping disease genes and in establishing founder effects.
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Registered trials
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