ArticleNucleic acids research1996
Pat1: a topoisomerase II-associated protein required for faithful chromosome transmission in Saccharomyces cerevisiae.
Article in Nucleic acids research, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 58 citations in OpenAlex.
- Domains of RNA-binding protein Ssd1 required for tolerating chromosome amplification in yeast.bioRxiv : the preprint server for biology · 2026Article
- Genomic Organization, Evolutionary Conservation and Expression ofBiomedicines · 2025Article
- Identification of novel variants and expansion of the phenotypic spectrum in PATL2, WEE2, and TUBB8 associated with human early embryonic arrest.Journal of assisted reproduction and genetics · 2025Article
- Picea wilsonii transcription factor NAC2 enhanced plant tolerance to abiotic stress and participated in RFCP1-regulated flowering time.Plant molecular biology · 2018Article
- The sole LSm complex inRNA (New York, N.Y.) · 2017Article
- Involvement of fission yeast Pdc2 in RNA degradation and P-body function.RNA (New York, N.Y.) · 2017Article
- Identification of KIAA1210 as a novel X-chromosome-linked protein that localizes to the acrosome and associates with the ectoplasmic specialization in testes.Biology of reproduction · 2017Article
- Topoisomerase II-associated protein PAT1H1 is involved in the root stem cell niche maintenance in Arabidopsis thaliana.Plant cell reports · 2016Article
- Genome-Based Selection and Characterization of Fusarium circinatum-Specific Sequences.G3 (Bethesda, Md.) · 2016Article
- Article
- Pat1 protects centromere-specific histone H3 variant Cse4 from Psh1-mediated ubiquitination.Molecular biology of the cell · 2015Article
- The mRNA decay factor PAT1 functions in a pathway including MAP kinase 4 and immune receptor SUMM2.The EMBO journal · 2015Article
- Pat1 contributes to the RNA binding activity of the Lsm1-7-Pat1 complex.RNA (New York, N.Y.) · 2014Article
- Structural integrity of centromeric chromatin and faithful chromosome segregation requires Pat1.Genetics · 2013Article
- Genome-wide scoring of positive and negative epistasis through decomposition of quantitative genetic interaction fitness matrices.PloS one · 2010Article
- Article
- Domain analysis of the tubulin cofactor system: a model for tubulin folding and dimerization.BMC bioinformatics · 2003Article
- The DEAD box protein Dhh1 stimulates the decapping enzyme Dcp1.The EMBO journal · 2002Article
- The yeast cytoplasmic LsmI/Pat1p complex protects mRNA 3' termini from partial degradation.Genetics · 2001Article
- The two proteins Pat1p (Mrt1p) and Spb8p interact in vivo, are required for mRNA decay, and are functionally linked to Pab1p.Molecular and cellular biology · 2000Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Saccharomyces cerevisiae top2 mutants deficient in topoisomerase II activity are defective in chromosome segregation during both mitotic and meiotic cell divisions. To identify proteins that act in concert with topoisomerase II during chromosome segregation in S.cerevisiae, we have used a two-hybrid cloning approach. We report the isolation of the PAT1 gene (for protein associated with topoisomerase II), which encodes a novel 90 kDa proline- and glutamine-rich protein that interacts with a highly conserved, leucine-rich region of topoisomerase II in vivo. Strains lacking Pat1p exhibit a slow growth rate and a phenotype reminiscent of conditional top2 mutants grown at the semi-permissive temperature; most notably, a reduced fidelity of chromosome segregation during both mitosis and meiosis. These findings indicate that the PAT1 gene is necessary for accurate chromosome transmission during cell division in eukaryotic cells and suggest that the interaction of Pat1p and topoisomerase II is an important component of this function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.