ArticleVirchows Archiv : an international journal of pathology1996
Differential reactivity of HBME-1 and CD15 antibodies in benign and malignant thyroid tumours. Preferential reactivity with malignant tumours.
Article in Virchows Archiv : an international journal of pathology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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28 citing papers in PubMed, 1 synthesis or guideline pooled it, 132 citations in OpenAlex.
- An In-Depth Evaluation of CD15 Expression in Thyroid Carcinoma: A Comprehensive Systematic Review.Cancer reports (Hoboken, N.J.) · 2026Pooled it
- Immunohistochemical profile of non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) versus other thyroid follicular lesions.Diagnostic pathology · 2025Article
- Serum Anti-Thyroglobulin Autoantibodies Are Specific in Predicting the Presence of Papillary-like Nuclear Features and Lymphocytic Infiltrate in the Thyroid Gland.Diagnostics (Basel, Switzerland) · 2023Article
- Immunohistochemical Biomarkers in Thyroid Pathology.Endocrine pathology · 2018Review
- Surgical treatment of thyroid follicular neoplasms: results of a retrospective analysis of a large clinical series.Endocrine · 2017Article
- Stage-Specific Embryonic Antigen-1 (SSEA-1) Expression in Thyroid Tissues.Endocrine pathology · 2016Article
- Pathology of Struma Ovarii: A Report of 96 Cases.Endocrine pathology · 2015Article
- Observational
- Utility of immunohistochemical markers in diagnosis of follicular cell derived thyroid lesions.Pathology oncology research : POR · 2014Article
- Monoclonal antibody HBME-1 reacts with a minor subset of B cells with villous surface and can be useful in the diagnosis of hairy cell leukemia and other indolent lymphoproliferations of villous B lymphocytes.Virchows Archiv : an international journal of pathology · 2013Article
- Immunocytochemical analysis for differential diagnosis of thyroid lesions using liquid-based cytology.Nagoya journal of medical science · 2011Article
- Diagnostic utility of immunohistochemical panel in various thyroid pathologies.Langenbeck's archives of surgery · 2010Article
- Thyroid tumours of uncertain malignant potential: frequency and diagnostic reproducibility.Virchows Archiv : an international journal of pathology · 2009Article
- Utility of malignancy markers in fine-needle aspiration cytology of thyroid nodules: comparison of Hector Battifora mesothelial antigen-1, thyroid peroxidase and dipeptidyl aminopeptidase IV.British journal of cancer · 2008Article
- Diagnostic value of galectin-3, HBME-1, cytokeratin 19, high molecular weight cytokeratin, cyclin D1 and p27(kip1) in the differential diagnosis of thyroid nodules.Journal of Korean medical science · 2007Article
- Microarray analysis of thyroid nodule fine-needle aspirates accurately classifies benign and malignant lesions.The Journal of molecular diagnostics : JMD · 2006Article
- Utility of BRAF V600E mutation detection in cytologically indeterminate thyroid nodules.CytoJournal · 2006Article
- The many faces and mimics of papillary thyroid carcinoma.Endocrine pathology · 2006Review
- Diagnostic value of differential expression of CK19, Galectin-3, HBME-1, ERK, RET, and p16 in benign and malignant follicular-derived lesions of the thyroid: an immunohistochemical tissue microarray analysis.Endocrine pathology · 2006Article
- Immunohistochemical separation of follicular variant of papillary thyroid carcinoma from follicular adenoma.Endocrine pathology · 2006Article
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2 authors at 2 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
We studied a wide range thyroid tumours and non-neoplastic conditions (total 463 cases) immunohistochemically to evaluate the possible diagnostic potential of HBME-1 and CD15 antibodies. HBME-1 monoclonal antibody recognizes a biochemically unknown epitope present in mesothelioma and variably present in some adenocarcinomas. CD15 antibodies recognize a sugar epitope also included in Lewis X blood group antigen. All papillary (145/145) and follicular carcinomas (27/27) were HBME-1 positive, usually in the the majority of tumour cells. In contrast, cases of nodular goitre and papillary hyperplasia either showed no reactivity or were focally positive (in a third of cases). The patterns of CD15 reactivity were generally similar, although smaller numbers of tumour cells were positive in papillary carcinomas, and only 50% of follicular carcinomas were positive. Because fetal thyroid also showed CD15 reactivity, this antigen appears to behave as an oncofetal antigen in relation to thyroid tissue. Anaplastic carcinomas were negative with both antibodies, indicating the loss of these epitopes upon high grade malignant transformation. We conclude that HBME-1 and CD15 immunohistochemistry may be helpful in the histological differential diagnosis between benign lesions and differentiated thyroid carcinomas, especially papillary tumours. Although the biochemical basis of HBME-1 reactivity is unknown, increased CD15 reactivity in malignant thyroid tumours probably reflects changes in thyroid follicular epithelial glycoconjugates related to malignant transformation.
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