ArticleMolecular and cellular biology1997
A complex containing two transcription factors regulates peroxisome proliferation and the coordinate induction of beta-oxidation enzymes in Saccharomyces cerevisiae.
Article in Molecular and cellular biology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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33 citing papers in PubMed, 86 citations in OpenAlex.
- The yeast peroxisomal proteome at absolute quantitative scale.Histochemistry and cell biology · 2026Article
- Acyl CoA oxidase: from its expression, structure, folding, and import to its role in human health and disease.Molecular genetics and genomics : MGG · 2023Review
- DNA variants affecting the expression of numerous genes in trans have diverse mechanisms of action and evolutionary histories.PLoS genetics · 2019Article
- A yeast phenomic model for the influence of Warburg metabolism on genetic buffering of doxorubicin.Cancer & metabolism · 2019Article
- Elucidating the Role of Chromatin State and Transcription Factors on the Regulation of the Yeast Metabolic Cycle: A Multi-Omic Integrative Approach.Frontiers in genetics · 2018Article
- Genetic architecture of ethanol-responsive transcriptome variation in Saccharomyces cerevisiae strains.Genetics · 2014Article
- Transcriptional regulation of the copper transporter mfc1 in meiotic cells.Eukaryotic cell · 2013Article
- The peroxisome: an update on mysteries.Histochemistry and cell biology · 2012Review
- Avoiding unscheduled transcription in shared promoters: Saccharomyces cerevisiae Sum1p represses the divergent gene pair SPS18-SPS19 through a midsporulation element (MSE).FEMS yeast research · 2009Article
- Drosophila HNF4 regulates lipid mobilization and beta-oxidation.Cell metabolism · 2009Article
- Mediator subunit Gal11p/MED15 is required for fatty acid-dependent gene activation by yeast transcription factor Oaf1p.The Journal of biological chemistry · 2009Article
- Control of transcriptional variability by overlapping feed-forward regulatory motifs.Biophysical journal · 2008Article
- Binding characteristics and regulatory mechanisms of the transcription factors controlling oleate-responsive genes in Saccharomyces cerevisiae.The Journal of biological chemistry · 2008Article
- The PEROXIN11 protein family controls peroxisome proliferation in Arabidopsis.The Plant cell · 2007Article
- A fungal family of transcriptional regulators: the zinc cluster proteins.Microbiology and molecular biology reviews : MMBR · 2006Review
- Fungi and animals may share a common ancestor to nuclear receptors.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Regulatory genes controlling fatty acid catabolism and peroxisomal functions in the filamentous fungus Aspergillus nidulans.Eukaryotic cell · 2006Article
- Mxr1p, a key regulator of the methanol utilization pathway and peroxisomal genes in Pichia pastoris.Molecular and cellular biology · 2006Article
- Pex30p, Pex31p, and Pex32p form a family of peroxisomal integral membrane proteins regulating peroxisome size and number in Saccharomyces cerevisiae.Molecular biology of the cell · 2004Article
- Conserved function of pex11p and the novel pex25p and pex27p in peroxisome biogenesis.Molecular biology of the cell · 2003Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Expression of the POX1 gene, which encodes peroxisomal acyl coenzyme A oxidase in the yeast Saccharomyces cerevisiae, is tightly regulated and can be induced by fatty acids such as oleate. Previously we have shown that this regulation is brought about by interactions between trans-acting factor(s) and an upstream activating sequence (UAS1) in the POX1 promoter. We recently identified and isolated a transcription factor, Oaf1p, that binds to the UAS1 of POX1 and mediates its induction. A screening strategy has been developed and used to identify eight S. cerevisiae mutants, from three complementation groups, that are defective in the oleate induction of POX1. Characterization of one such mutant led to the identification of Oaf2p, a protein that is 39% identical to Oaf1p. Oaf1p and Oaf2p form a protein complex that is required for the activation of POX1 and FOX3 and for proliferation of peroxisomes. We propose a model in which these two transcription factors heterodimerize and mediate this activation process. The mutants that we have isolated, and further identification of the corresponding defective genes, provide us with an opportunity to characterize the mechanisms involved in the coordinate regulation of peroxisomal beta-oxidation enzymes.
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