ArticleMolecular and cellular biology1997
Suppression of grp78 core promoter element-mediated stress induction by the dbpA and dbpB (YB-1) cold shock domain proteins.
Article in Molecular and cellular biology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 64 citations in OpenAlex.
- Article
- Expression and network analysis of YBX1 interactors for identification of new drug targets in lung adenocarcinoma.Journal of genomics · 2018Article
- Cold Shock Proteins Mediate GN with Mesangioproliferation.Journal of the American Society of Nephrology : JASN · 2016Article
- PARP-1 and YY1 are important novel regulators of CXCL12 gene transcription in rat pancreatic beta cells.PloS one · 2013Article
- YY1-binding sites provide central switch functions in the PARP-1 gene expression network.PloS one · 2012Article
- Proteomic analysis of endothelial cold-adaptation.BMC genomics · 2011Article
- Analysis of overrepresented motifs in human core promoters reveals dual regulatory roles of YY1.Genome research · 2007Article
- The transcriptional factor YY1 upregulates the novel invasion suppressor HLJ1 expression and inhibits cancer cell invasion.Oncogene · 2005Article
- A novel mechanism of repression of the vascular endothelial growth factor promoter, by single strand DNA binding cold shock domain (Y-box) proteins in normoxic fibroblasts.Nucleic acids research · 2002Article
- Novel translational control through an iron-responsive element by interaction of multifunctional protein YB-1 and IRP2.Molecular and cellular biology · 2002Article
- Functional interaction between JC virus late regulatory agnoprotein and cellular Y-box binding transcription factor, YB-1.Journal of virology · 2002Article
- Direct interaction of p53 with the Y-box binding protein, YB-1: a mechanism for regulation of human gene expression.Oncogene · 2000Article
- Thrombin activates a Y box-binding protein (DNA-binding protein B) in endothelial cells.The Journal of clinical investigation · 2000Article
- ATF6 as a transcription activator of the endoplasmic reticulum stress element: thapsigargin stress-induced changes and synergistic interactions with NF-Y and YY1.Molecular and cellular biology · 2000Article
- Nucleolin and YB-1 are required for JNK-mediated interleukin-2 mRNA stabilization during T-cell activation.Genes & development · 2000Article
- Physical and functional interaction between the Y-box binding protein YB-1 and human polyomavirus JC virus large T antigen.Journal of virology · 1999Article
- Reciprocal interaction between two cellular proteins, Puralpha and YB-1, modulates transcriptional activity of JCVCY in glial cells.Molecular and cellular biology · 1999Article
- Role of the transcription start site core region and transcription factor YY1 in Rous sarcoma virus long terminal repeat promoter activity.Journal of virology · 1998Article
- The constitutive heat shock protein-70 is required for optimal expression of myelin basic protein during differentiation of oligodendrocytes.Neurochemical research · 1998Article
- Induction of the mammalian GRP78/BiP gene by Ca2+ depletion and formation of aberrant proteins: activation of the conserved stress-inducible grp core promoter element by the human nuclear factor YY1.Molecular and cellular biology · 1997Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
The highly conserved grp78 core promoter element plays an important role in the induction of grp78 under diverse stress signals. Previous studies have established a functional region in the 3' half of the core (stress-inducible change region [SICR]) which exhibits stress-inducible changes in stressed nuclei. The human transcription factor YY1 is shown to bind the SICR and transactivate the core element under stress conditions. Here we report that expression library screening with the core element has identified two new core binding proteins, YB-1 and dbpA. Both proteins belong to the Y-box family of proteins characterized by an evolutionarily conserved DNA binding motif, the cold shock domain (CSD). In contrast to YY1, which binds only double-stranded SICR, the Y-box/CSD proteins much prefer the lower strand of the SICR. The Y-box proteins can repress the inducibility of the grp78 core element mediated by treatment of cells with A23187, thapsigargin, and tunicamycin. In gel shift assays, YY1 binding to the core element is inhibited by either YB-1 or dbpA. A yeast interaction trap screen using LexA-YY1 as a bait and a HeLa cell cDNA-acid patch fusion library identified YB-1 as a YY1-interacting protein. In cotransfection experiments, the Y-box proteins antagonize the YY1-mediated enhancement of transcription directed by the grp78 core in stressed cells. Thus, the CSD proteins may be part of the stress signal transduction mechanism in the mammalian system.
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