ArticleMolecular and cellular biology1997
The mammalian transcriptional repressor RBP (CBF1) regulates interleukin-6 gene expression.
Article in Molecular and cellular biology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 80 citations in OpenAlex.
- Orphan nuclear receptor NR4A1 regulates both osteoblastogenesis and adipogenesis in human mesenchymal stem cells.Molecular medicine reports · 2025Article
- RBPJ contributes to the malignancy of glioblastoma and induction of proneural-mesenchymal transition via IL-6-STAT3 pathway.Cancer science · 2020Article
- Concurrent activation of growth factor and nutrient arms of mTORC1 induces oxidative liver injury.Cell discovery · 2019Article
- Notch signaling regulates cell density-dependent apoptosis of NIH 3T3 through an IL-6/STAT3 dependent mechanism.European journal of cell biology · 2018Article
- NICD-mediated notch transduction regulates the different fate of chicken primordial germ cells and spermatogonial stem cells.Cell & bioscience · 2018Article
- Hall of Fame among Pro-inflammatory Cytokines: Interleukin-6 Gene and Its Transcriptional Regulation Mechanisms.Frontiers in immunology · 2016Review
- The human cytomegalovirus UL26 protein antagonizes NF-κB activation.Journal of virology · 2014Article
- Modulation of NF-κB-dependent gene transcription using programmable DNA minor groove binders.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- MeCP2/H3meK9 are involved in IL-6 gene silencing in pancreatic adenocarcinoma cell lines.Nucleic acids research · 2009Article
- NF-kappaB serves as a cellular sensor of Kaposi's sarcoma-associated herpesvirus latency and negatively regulates K-Rta by antagonizing the RBP-Jkappa coactivator.Journal of virology · 2009Article
- A novel RBP-J kappa-dependent switch from C/EBP beta to C/EBP zeta at the C/EBP binding site on the C-reactive protein promoter.Journal of immunology (Baltimore, Md. : 1950) · 2007Article
- Differential transcriptional control of the superoxide dismutase-2 kappaB element in neurons and astrocytes.The Journal of biological chemistry · 2006Article
- An NRSF/REST-like repressor downstream of Ebi/SMRTER/Su(H) regulates eye development in Drosophila.The EMBO journal · 2006Article
- Innate immune responses in NF-kappaB-repressing factor-deficient mice.Molecular and cellular biology · 2006Article
- RBP-J (CSL) is essential for activation of the K14/vGPCR promoter of Kaposi's sarcoma-associated herpesvirus by the lytic switch protein RTA.Journal of virology · 2004Article
- p38 MAPK regulates IL-1beta induced IL-6 expression through mRNA stability in osteoblasts.Immunological investigations · 2004Article
- Epstein-Barr Virus nuclear protein EBNA3A is critical for maintaining lymphoblastoid cell line growth.Journal of virology · 2003Article
- Direct induction of T lymphocyte-specific gene expression by the mammalian Notch signaling pathway.Genes & development · 2002Article
- Alterations in NF-kappaB and RBP-Jkappa by arenavirus infection of macrophages in vitro and in vivo.Journal of virology · 2002Article
- Amino acids of Epstein-Barr virus nuclear antigen 3A essential for repression of Jkappa-mediated transcription and their evolutionary conservation.Journal of virology · 2001Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The cellular interleukin-6 (IL-6) gene contains a target site for the mammalian transcriptional repressor RBP. The target site is contained within the interleukin response element (ILRE), which mediates IL-6 activation by NF-kappa B. In this study, we show by using transient-expression assays that RBP represses activated transcription from the IL-6 gene. The presence and position of the RBP target site are crucial in mediating repression by RBP. While RBP binds within the ILRE, it does not target NF-kappa B alone; nonetheless, NF-kappa B binding to the ILRE is required for repression. Our results indicate that RBP represses coactivation by NF-kappa B and another cellular transcription factor, C/EBP-beta.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.