ArticleMolecular biology of the cell1996
Domains determining the functional distinction of the fission yeast cell cycle "start" molecules Res1 and Res2.
Article in Molecular biology of the cell, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 12 citations in OpenAlex.
- Structural basis of DNA recognition by PCG2 reveals a novel DNA binding mode for winged helix-turn-helix domains.Nucleic acids research · 2015Article
- The cell cycle-regulated genes of Schizosaccharomyces pombe.PLoS biology · 2005Article
- DSC1-MCB regulation of meiotic transcription in Schizosaccharomyces pombe.Molecular genetics and genomics : MGG · 2004Article
- A pcl-like cyclin activates the Res2p-Cdc10p cell cycle "start" transcriptional factor complex in fission yeast.Molecular biology of the cell · 2000Article
- Cell cycle-regulated transcription in fission yeast: Cdc10-Res protein interactions during the cell cycle and domains required for regulated transcription.Molecular biology of the cell · 1999Article
- Functional domains of rep2, a transcriptional activator subunit for Res2-Cdc10, controlling the cell cycle "start".Molecular biology of the cell · 1998Article
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2 authors at 1 institution in 1 country.
Funding
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Abstract
In Schizosaccharomyces pombe the "start" of the cell cycle is regulated by two parallel, functionally overlapping complexes composed of Res1-Cdc10 and Res2-Cdc10. Res1 and Res2 are structurally very homologous and are required for the start of the mitotic and meiotic cycle, respectively. We have addressed the question which parts of the proteins are essential for function and determine the functional specificity. Several discrete domains in the nonconserved C-terminal region are essential for the mitotic and meiotic start function and determine the functional specificity independently of the structurally conserved motifs at the N-terminal end and in the center. One of these domains in Res2 restricts Res2 to interact only with Rep2. Res2 without this domain behaves like a functional chimera having the properties of Res2 and Res1. Likewise, internally truncated forms of Res1 lacking the centrally located ankyrin repeats and adjacent sequences can partially suppress the meiotic defect in res2- cells. These truncated Res1 molecules behave like functional chimeras with the properties of Res1 and Res2.
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