ReviewEmerging infectious diseases
New vaccines for the prevention of pneumococcal infections.
Review in Emerging infectious diseases. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- A Review of Vaccinations in Adult Patients with Secondary Immunodeficiency.Infectious diseases and therapy · 2021Review
- Adhesion and invasion of Streptococcus pneumoniae to primary and secondary respiratory epithelial cells.Molecular medicine reports · 2017Article
- Selective Subnormal IgG1 in 54 Adult Index Patients with Frequent or Severe Bacterial Respiratory Tract Infections.Journal of immunology research · 2016Article
- Article
- Clinical implications of pneumococcal serotypes: invasive disease potential, clinical presentations, and antibiotic resistance.Journal of Korean medical science · 2013Review
- Immune Responses to pneumococcal vaccines in children and adults: Rationale for age-specific vaccination.Aging and disease · 2012Article
- Cancer vaccines and carbohydrate epitopes.Vaccine · 2011Review
- Trends in incidence of pneumococcal disease before introduction of conjugate vaccine: South West England, 1996-2005.Epidemiology and infection · 2008Article
- Combination vaccine against invasive meningococcal B and pneumococcal infections: potential epidemiological and economic impact in the Netherlands.PharmacoEconomics · 2006Article
- Age-dependent preference in human antibody responses to Streptococcus pneumoniae polypeptide antigens.Clinical and experimental immunology · 2002Article
- Identification of the psaA gene, coding for pneumococcal surface adhesin A, in viridans group streptococci other than Streptococcus pneumoniae.Clinical and diagnostic laboratory immunology · 2001Article
- Identification and characterization of a novel family of pneumococcal proteins that are protective against sepsis.Infection and immunity · 2001Article
- Combinatorial library cloning of human antibodies to Streptococcus pneumoniae capsular polysaccharides: variable region primary structures and evidence for somatic mutation of Fab fragments specific for capsular serotypes 6B, 14, and 23F.Infection and immunity · 2001Article
- CpG oligodeoxynucleotides act as adjuvants for pneumococcal polysaccharide-protein conjugate vaccines and enhance antipolysaccharide immunoglobulin G2a (IgG2a) and IgG3 antibodies.Infection and immunity · 2000Article
- Intranasal immunization with pneumococcal polysaccharide conjugate vaccines with nontoxic mutants of Escherichia coli heat-labile enterotoxins as adjuvants protects mice against invasive pneumococcal infections.Infection and immunity · 1999Article
- Avidity as a determinant of the protective efficacy of human antibodies to pneumococcal capsular polysaccharides.Infection and immunity · 1999Article
- Pneumococcal diversity: considerations for new vaccine strategies with emphasis on pneumococcal surface protein A (PspA).Clinical microbiology reviews · 1998Review
- Use of licensed vaccines for active immunization of the immunocompromised host.Clinical microbiology reviews · 1998Review
- Oligoclonality of serum immunoglobulin G antibody responses to Streptococcus pneumoniae capsular polysaccharide serotypes 6B, 14, and 23F.Infection and immunity · 1997Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Streptococcus pneumoniae is a major cause of acute otitis media, pneumonia, bacteremia, and meningitis. Because in recent years antibiotic-resistant pneumococcal strains have been emerging throughout the world, vaccination against pneumococcal infections has become more urgent. The capsular polysaccharide vaccine that has been available is neither immunogenic nor protective in young children and other immunocompromised patients. Several pneumococcal proteins have been proposed as candidate vaccines, but no human studies associated with them have been reported. Clinical trials of first-generation pneumococcal conjugate vaccines have shown that covalent coupling of pneumococcal capsular polysaccharides to protein carriers improves the immunogenicity of the polysaccharides. The protective efficacy of the conjugate vaccines against carriage, acute otitis media, and invasive infections is being studied.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.