ReviewJournal of molecular neuroscience : MN1996
Activity-dependent neurotrophic factor (ADNF). An extracellular neuroprotective chaperonin?
Review in Journal of molecular neuroscience : MN, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 61 citations in OpenAlex.
- Neuroprotective Peptide NAPVSIPQ Antagonizes Ethanol Inhibition of L1 Adhesion by Promoting the Dissociation of L1 and Ankyrin-G.Biological psychiatry · 2020Article
- Microtubule stabilising peptides rescue tau phenotypes in-vivo.Scientific reports · 2016Article
- D-SAL and NAP: Two Peptides Sharing a SIP Domain.Journal of molecular neuroscience : MN · 2016Article
- Selective VIP Receptor Agonists Facilitate Immune Transformation for Dopaminergic Neuroprotection in MPTP-Intoxicated Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- D-NAP prophylactic treatment in the SOD mutant mouse model of amyotrophic lateral sclerosis: review of discovery and treatment of tauopathy.Journal of molecular neuroscience : MN · 2012Review
- Nur(R1)turing a notion on the etiopathogenesis of Parkinson's disease.Neurotoxicity research · 2009Article
- NAP and D-SAL: neuroprotection against the beta amyloid peptide (1-42).BMC neuroscience · 2008Article
- VIP, from gene to behavior and back: summarizing my 25 years of research.Journal of molecular neuroscience : MN · 2008Article
- Peptidergic agonists of activity-dependent neurotrophic factor protect against prenatal alcohol-induced neural tube defects and serotonin neuron loss.Alcoholism, clinical and experimental research · 2008Article
- Tubulin is the target binding site for NAP-related peptides: ADNF-9, D-NAP, and D-SAL.Journal of molecular neuroscience : MN · 2006Article
- Chaperones and proteases: cellular fold-controlling factors of proteins in neurodegenerative diseases and aging.Journal of molecular neuroscience : MN · 2006Review
- PolyADP-ribosylation is involved in neurotrophic activity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- NAP: research and development of a peptide derived from activity-dependent neuroprotective protein (ADNP).CNS drug reviews · 2005Review
- Activity-dependent neurotrophic factor-9 and NAP promote neurite outgrowth in rat hippocampal and cortical cultures.Journal of molecular neuroscience : MN · 2005Article
- Subcellular localization and secretion of activity-dependent neuroprotective protein in astrocytes.Neuron glia biology · 2004Article
- A neuroprotective peptide antagonizes fetal alcohol exposure-compromised brain growth.Journal of molecular neuroscience : MN · 2004Article
- Effects of the vasoactive intestinal peptide (VIP) and related peptides on glioblastoma cell growth in vitro.Journal of molecular neuroscience : MN · 2003Article
- Insulin-like growth factor I (IGF-I) protects cells from apoptosis by Alzheimer's V642I mutant amyloid precursor protein through IGF-I receptor in an IGF-binding protein-sensitive manner.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
- VIP and peptides related to activity-dependent neurotrophic factor protect PC12 cells against oxidative stress.Journal of molecular neuroscience : MN · 2000Article
- VIP-Related protection against lodoacetate toxicity in pheochromocytoma (PC12) cells: a model for ischemic/hypoxic injury.Journal of molecular neuroscience : MN · 2000Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To understand and intervene in neuronal cell death, intensive investigations have been directed at the discovery of intracellular and extracellular factors that provide natural neuroprotection. This goal has fundamental importance for both rational strategies for the treatment of neurodegenerative diseases and also the delineation of molecular mechanisms that regulate nervous system differentiation and growth. We have discovered a potential interface among these fields of research with activity-dependent neurotrophic factor (ADNF), a protein containing sequence homologies to intracellular stress proteins that is found in the extracellular milieu of astroglial cells incubated with the neuropeptide vasoactive intestinal peptide (VIP). Femtomolar concentrations of ADNF and a short peptide sequence derived from it (a peptidergic active site) protected neurons from death associated with a broad range of toxins, including those related to Alzheimer's disease, the human immunodeficiency virus, excito-toxicity, and electrical blockade. Because the activity of the protein was mimicked by a short peptide fragment, this peptide is now proposed as a lead compound for drug development against neurodegeneration.
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