ArticleJournal of clinical microbiology1997
Rabbit model for Chlamydia pneumoniae infection.
Article in Journal of clinical microbiology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
52 citing papers in PubMed, 259 citations in OpenAlex.
- The role of infected epithelial cells inFrontiers in cellular and infection microbiology · 2023Review
- Pathogens in Vasculitis: Is It Really Idiopathic?JMA journal · 2021Review
- Detection of specific Chlamydia pneumoniae and cytomegalovirus antigens in human carotid atherosclerotic plaque in a Chinese population.Oncotarget · 2017Article
- Characterization of New Zealand White Rabbit Gut-Associated Lymphoid Tissues and Use as Viral Oncology Animal Model.ILAR journal · 2016Article
- Association of Chlamydia pneumoniae Infection With Atherosclerotic Plaque Formation.Global journal of health science · 2015Article
- Chlamydia pneumoniae infection in atherosclerotic lesion development through oxidative stress: a brief overview.International journal of molecular sciences · 2013Review
- Quantitative RT-PCR profiling of the rabbit immune response: assessment of acute Shigella flexneri infection.PloS one · 2012Article
- Oral azithromycin in extended dosage schedule for chronic, subclinical Chlamydia pneumoniae infection causing coronary artery disease: a probable cure in sight? Results of a controlled preliminary trial.International journal of general medicine · 2012Article
- Strategies and methods to study sex differences in cardiovascular structure and function: a guide for basic scientists.Biology of sex differences · 2011Article
- Infection and vasculitis.Rheumatology (Oxford, England) · 2009Review
- TLR/MyD88 and liver X receptor alpha signaling pathways reciprocally control Chlamydia pneumoniae-induced acceleration of atherosclerosis.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- The role of infectious agents in the pathogenesis of vasculitis.Best practice & research. Clinical rheumatology · 2008Review
- Chlamydia pneumoniae replicates in Kupffer cells in mouse model of liver infection.World journal of gastroenterology · 2006Article
- Development of diabetes in non-obese diabetic mice promotes Chlamydia pneumoniae dissemination from lung to peripheral blood.International journal of experimental pathology · 2006Article
- Degradation of Chlamydia pneumoniae by peripheral blood monocytic cells.Infection and immunity · 2005Article
- Presence of Chlamydia pneumoniae in patients with and without atherosclerosis.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2005Article
- Development of a hamster model of Chlamydophila pneumoniae infection.Veterinary research communications · 2005Article
- Heat-inactivated C. pneumoniae organisms are not atherogenic.Molecular and cellular biochemistry · 2004Article
- Is Chlamydia pneumoniae infection a risk factor for age related macular degeneration?The British journal of ophthalmology · 2003Article
- Dissemination of Chlamydia pneumoniae to the vessel wall in atherosclerosis.Molecular and cellular biochemistry · 2003Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A rabbit model was established for Chlamydia pneumoniae infection that may be helpful to understand the pathogenesis of disease in humans. Twelve, pathogen-free, 1-month-old New Zealand White rabbits were inoculated with 1.0 x 10(7) to 5.0 x 10(7) CFU of purified C. pneumoniae (ATCC strain VR 1310) via the nasopharynx (1 rabbit died immediately postinoculation, and 11 were available for study). Five controls were inoculated with the carrier buffer. Ten of the 11 study rabbits demonstrated serological evidence of acute infection (immunoglobulin G antibodies, 1:8 to > 1:16), with the weakest response at 7 days and the strongest response at 28 days, whereas none of the controls showed any seroconversion. Study animals were sacrificed in batches of three, on days 7, 14, 21, and 28, but controls were sacrificed on days 7 and 28. Two-thirds of the animals demonstrated evidence of bronchiolitis and pneumonia on days 7 and 14 and resolution by day 21. Two study rabbits demonstrated, on histology, early and intermediate lesions of atherosclerosis: one animal (day 7) showed the accumulation of foamy macrophages (fatty streak) in the arch of the aorta, and the other animal (day 14) showed spindle cell proliferation of smooth muscle cells (intermediate lesion). Focal periaortitis was seen in the same animal (day 7). C. pneumoniae elementary bodies were demonstrated by immunocytochemical stain in the lungs (n = 2), liver (n = 3), spleen (n = 5), and aorta (n = 2), one of which corresponded to the intermediate lesion. C. pneumoniae was cultured from the lungs (n = 2), liver (n = 2), spleen (n = 2), and aortic arch (n = 1). All histopathological, immunocytochemical, and cultural studies were negative in the controls. Hence, the rabbit provides a useful animal model for the study of C. pneumoniae infection and its complications, particularly atherosclerosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.