ArticleBiophysical journal1996
A minimal gating model for the cardiac calcium release channel.
Article in Biophysical journal, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Quenching the spark: Termination of CICR in the submicroscopic space of the dyad.The Journal of general physiology · 2017Review
- Calcium oscillations.Cold Spring Harbor perspectives in biology · 2011Review
- Integrative systems models of cardiac excitation-contraction coupling.Circulation research · 2011Review
- Modeling CICR in rat ventricular myocytes: voltage clamp studies.Theoretical biology & medical modelling · 2010Article
- Frequency and release flux of calcium sparks in rat cardiac myocytes: a relation to RYR gating.The Journal of general physiology · 2010Article
- Local calcium release activation by DHPR calcium channel openings in rat cardiac myocytes.The Journal of physiology · 2008Article
- Alternans of cardiac calcium cycling in a cluster of ryanodine receptors: a simulation study.American journal of physiology. Heart and circulatory physiology · 2008Article
- Mode switching is the major mechanism of ligand regulation of InsP3 receptor calcium release channels.The Journal of general physiology · 2007Article
- Modelling calcium microdomains using homogenisation.Journal of theoretical biology · 2007Article
- Ca2+ stores regulate ryanodine receptor Ca2+ release channels via luminal and cytosolic Ca2+ sites.Biophysical journal · 2007Article
- Kinetics of calcium spikes in rat cardiac myocytes.The Journal of physiology · 2007Article
- Calcium activation of ryanodine receptor channels--reconciling RyR gating models with tetrameric channel structure.The Journal of general physiology · 2005Article
- A simplified local control model of calcium-induced calcium release in cardiac ventricular myocytes.Biophysical journal · 2004Article
- A mathematical treatment of integrated Ca dynamics within the ventricular myocyte.Biophysical journal · 2004Article
- Calcium regulation of single ryanodine receptor channel gating analyzed using HMM/MCMC statistical methods.The Journal of general physiology · 2004Article
- A mathematical analysis of the generation and termination of calcium sparks.Biophysical journal · 2004Article
- Kinetic studies of calcium-induced calcium release in cardiac sarcoplasmic reticulum vesicles.Biophysical journal · 2003Article
- Kinetic model of the inositol trisphosphate receptor that shows both steady-state and quantal patterns of Ca2+ release from intracellular stores.The Biochemical journal · 2003Article
- An integrative model of the cardiac ventricular myocyte incorporating local control of Ca2+ release.Biophysical journal · 2002Article
- Termination of cardiac Ca(2+) sparks: an investigative mathematical model of calcium-induced calcium release.Biophysical journal · 2002Article
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Authors and funding
2 authors.
Funding
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Abstract
A Markovian model of the cardiac Ca release channel, based on experimental single-channel gating data, was constructed to understand the transient nature of Ca release. The rate constants for a minimal gating scheme with one Ca-free resting state, and with two open and three closed states with one bound Ca2+, were optimized to simulate the following experimental findings. In steady state the channel displays three modes of activity: inactivated 1 mode without openings, low-activity L mode with single openings, and high-activity H mode with bursts of openings. At the onset of a Ca2+ step, the channel first activates in H mode and then slowly relaxes to a mixture of all three modes, the distribution of which depends on the new Ca2+. The corresponding ensemble current shows rapid activation, which is followed by a slow partial inactivation. The transient reactivation of the channel (increment detection) in response to successive additions of Ca2+ is then explained by the model as a gradual recruitment of channels from the extant pool of channels in the resting state. For channels in a living cell, the model predicts a high level of peak activation, a high extent of inactivation, and rapid deactivation, which could underlie the observed characteristics of the elementary release events (calcium sparks).
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