ArticleBritish journal of pharmacology1996
Cloned and transfected P2Y4 receptors: characterization of a suramin and PPADS-insensitive response to UTP.
Article in British journal of pharmacology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 89 citations in OpenAlex.
- Advances in nucleotide-based P2Y₁ antagonism: implications for cardiovascular therapeutics.Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2026Review
- P2YFrontiers in immunology · 2023Article
- P2YInternational journal of molecular sciences · 2020Article
- Profiling of a suramin-derived compound library at recombinant human P2Y receptors identifies NF272 as a competitive but non-selective P2YPurinergic signalling · 2019Article
- P2Y2 receptors mediate ATP-induced resensitization of TRPV1 expressed by kidney projecting sensory neurons.American journal of physiology. Regulatory, integrative and comparative physiology · 2010Article
- Characterization of Calcium-Mediated Intracellular and Intercellular Signaling in the rMC-1 Glial Cell Line.Cellular and molecular bioengineering · 2009Article
- Stimulation of rat erythrocyte P2X7 receptor induces the release of epoxyeicosatrienoic acids.British journal of pharmacology · 2007Article
- Apical membrane P2Y4 purinergic receptor controls K+ secretion by strial marginal cell epithelium.Cell communication and signaling : CCS · 2005Article
- Modulation of endothelial cell migration by extracellular nucleotides: involvement of focal adhesion kinase and phosphatidylinositol 3-kinase-mediated pathways.Thrombosis and haemostasis · 2005Article
- ATP and UTP responses of cultured rat aortic smooth muscle cells revisited: dominance of P2Y2 receptors.British journal of pharmacology · 2003Article
- Extended pharmacological profiles of rat P2Y2 and rat P2Y4 receptors and their sensitivity to extracellular H+ and Zn2+ ions.British journal of pharmacology · 2003Article
- P2Y receptor regulation of cultured rat cerebral cortical cells: calcium responses and mRNA expression in neurons and glia.British journal of pharmacology · 2003Article
- Acute downregulation of Cx43 alters P2Y receptor expression levels in mouse spinal cord astrocytes.Glia · 2003Article
- Regional variation in P2 receptor expression in the rat pulmonary arterial circulation.British journal of pharmacology · 2002Article
- Nucleotide-mediated relaxation in guinea-pig aorta: selective inhibition by MRS2179.British journal of pharmacology · 2002Article
- Evidence that rat hepatocytes co-express functional P2Y1 and P2Y2 receptors.British journal of pharmacology · 2000Article
- Effects of P(1) and P2 receptor antagonists on beta, gamma-methyleneATP- and CGS21680-induced cyclic AMP formation in NG108-15 cells.British journal of pharmacology · 2000Article
- Pyrimidine nucleotide-stimulated thromboxane A2 release from cultured glia.Cellular and molecular neurobiology · 1998Article
- Nucleotide receptors in the nervous system. An abundant component using diverse transduction mechanisms.Molecular neurobiology · 1997Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The P2Y family of receptors are G protein-coupled receptors for ATP, ADP, UTP and UDP. Recently several members of this family have been cloned, including the P2Y4, which is activated by UTP but not by ATP. In the present report, using receptors stably transfected into 1321N1 cells, we show that suramin acts as an antagonist at cloned P2Y1 and (less potently) P2Y2 receptors, but not at the cloned P2Y4 receptor. Furthermore, PPADS (pyridoxal-phosphate-6-azophenyl-2',4'-disulphonic acid), a potent antagonist at the P2Y1 receptor, is a relatively inneffective antagonist at the cloned P2Y4 receptor. This work moves us closer to the goal of classifying the native P2Y receptors on the basis of agonist and antagonist profiles.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.