ArticleProceedings of the National Academy of Sciences of the United States of America1996
A metric map of humans: 23,500 loci in 850 bands.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
77 citing papers in PubMed, 1 synthesis or guideline pooled it, 262 citations in OpenAlex.
- Meta-analysis of whole-genome linkage scans of bipolar disorder and schizophrenia.Molecular psychiatry · 2002Pooled it
- A first trial of retrospective collaboration for positional cloning in complex inheritance: assay of the cytokine region on chromosome 5 by the consortium on asthma genetics (COAG).Proceedings of the National Academy of Sciences of the United States of America · 2000Trial
- Mapping of meiotic recombination in human preimplantation blastocysts.G3 (Bethesda, Md.) · 2023Article
- Structure and size variations between 12A and 12D homoeologous chromosomes based on high-resolution cytogenetic map in allotetraploid cotton.Chromosoma · 2010Article
- Biochemical and molecular diagnosis of erythropoietic protoporphyria in an Ashkenazi Jewish family.Journal of inherited metabolic disease · 2008Article
- A comparative location database (CompLDB): map integration within and between species.Mammalian genome : official journal of the International Mammalian Genome Society · 2007Article
- Identification of sequence motifs at the breakpoint junctions in three t(1;9)(p36.3;q34) and delineation of mechanisms involved in generating balanced translocations.Human genetics · 2006Article
- Quantification of homozygosity in consanguineous individuals with autosomal recessive disease.American journal of human genetics · 2006Article
- Hereditary hypophosphatemic rickets with hypercalciuria is caused by mutations in the sodium-phosphate cotransporter gene SLC34A3.American journal of human genetics · 2006Article
- Fifty years of genetic epidemiology, with special reference to Japan.Journal of human genetics · 2006Review
- A map of the human genome in linkage disequilibrium units.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Linkage disequilibrium maps and association mapping.The Journal of clinical investigation · 2005Review
- Impact of population structure, effective bottleneck time, and allele frequency on linkage disequilibrium maps.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Linkage/association study of a locus modulating total serum IgE on chromosome 14q13-24 in families with asthma.Thorax · 2004Article
- Evidence for interaction between the TCO and NMTC1 loci in familial non-medullary thyroid cancer.Journal of medical genetics · 2004Article
- Mutation hotspots in the human porphobilinogen deaminase gene: recurrent mutations G111R and R173Q occurring at CpG motifs.Journal of inherited metabolic disease · 2004Article
- Pooled analysis of loss of heterozygosity in breast cancer: a genome scan provides comparative evidence for multiple tumor suppressors and identifies novel candidate regions.American journal of human genetics · 2003Article
- A 122.5-kilobase deletion of the P gene underlies the high prevalence of oculocutaneous albinism type 2 in the Navajo population.American journal of human genetics · 2003Article
- Chromosome localization analysis of genes strongly expressed in human visceral adipose tissue.Endocrine · 2002Article
- Systematic evaluation of map quality: human chromosome 22.American journal of human genetics · 2002Article
17 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
High-resolution maps integrated with the enhanced location data base software (LDB+) give improved estimates of genetic parameters and reveal characteristics of cytogenetic bands. Chiasma interference is intermediate between Kosambi and Carter-Falconer levels, as in Drosophila and the mouse. The autosomal genetic map is 2832 and 4348 centimorgans in males and females, respectively. Telomeric T-bands are strikingly associated with male recombination and gene density. Position and centromeric heterochromatin have large effects, but nontelomeric R-bands are not significantly different from G-bands. Several possible reasons are discussed. These regularities validate the maps, despite their high resolution and inevitable local errors. No other approach has been demonstrated to integrate such a large number of loci, which are increasing at about 45% per year. The maps and the data and software from which they are constructed are available through the Internet (http:@cedar.genetics.soton.ac.uk/public_html). Successive versions of this location data base may also be accessed on CD-ROM.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.