ArticleProceedings of the National Academy of Sciences of the United States of America1996
Presence of a mitochondrial-type 70-kDa heat shock protein in Trichomonas vaginalis suggests a very early mitochondrial endosymbiosis in eukaryotes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 187 citations in OpenAlex.
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- Prenylquinones in Human Parasitic Protozoa: Biosynthesis, Physiological Functions, and Potential as Chemotherapeutic Targets.Molecules (Basel, Switzerland) · 2019Review
- The Physiology of Phagocytosis in the Context of Mitochondrial Origin.Microbiology and molecular biology reviews : MMBR · 2017Review
- Sequence analysis of the Hsp70 family in moss and evaluation of their functions in abiotic stress responses.Scientific reports · 2016Article
- Diversity and origins of anaerobic metabolism in mitochondria and related organelles.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Review
- Biochemistry and evolution of anaerobic energy metabolism in eukaryotes.Microbiology and molecular biology reviews : MMBR · 2012Review
- Mitochondrion-related organelles in eukaryotic protists.Annual review of microbiology · 2010Review
- Five questions about microsporidia.PLoS pathogens · 2009Article
- Origin of the nucleus and Ran-dependent transport to safeguard ribosome biogenesis in a chimeric cell.Biology direct · 2008Article
- Genetic evidence for a mitochondriate ancestry in the 'amitochondriate' flagellate Trimastix pyriformis.PloS one · 2008Article
- Evolutionary analysis of the small heat shock proteins in five complete algal genomes.Journal of molecular evolution · 2007Article
- Prokaryotic and eukaryotic features observed on the secondary structures of Giardia SSU rRNAs and its phylogenetic implications.Parasitology research · 2007Article
- Origin of phagotrophic eukaryotes as social cheaters in microbial biofilms.Biology direct · 2007Article
- Mitochondria, hydrogenosomes and mitosomes: products of evolutionary tinkering!Current genetics · 2006Review
- Multiple secondary origins of the anaerobic lifestyle in eukaryotes.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2006Review
- Cardiolipin in hydrogenosomes: evidence of symbiotic origin.Eukaryotic cell · 2006Article
- Phylogenetic analysis of the complete genome sequence of Encephalitozoon cuniculi supports the fungal origin of microsporidia and reveals a high frequency of fast-evolving genes.Journal of molecular evolution · 2004Article
- Cryptosporidium parvum mitochondrial-type HSP70 targets homologous and heterologous mitochondria.Eukaryotic cell · 2004Article
- Hydrogen peroxide induces caspase activation and programmed cell death in the amitochondrial Tritrichomonas foetus.Histochemistry and cell biology · 2003Article
- Complete sequence of the mitochondrial genome of Tetrahymena thermophila and comparative methods for identifying highly divergent genes.Nucleic acids research · 2003Article
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Authors and funding
3 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Molecular phylogenetic analyses, based mainly on ribosomal RNA, show that three amitochondriate protist lineages, diplomonads, microsporidia, and trichomonads, emerge consistently at the base of the eukaryotic tree before groups having mitochondria. This suggests that these groups could have diverged before the mitochondrial endosymbiosis. Nevertheless, since all these organisms live in anaerobic environments, the absence of mitochondria might be due to secondary loss, as demonstrated for the later emerging eukaryote Entamoeba histolytica. We have now isolated from Trichomonas vaginalis a gene encoding a chaperone protein (HSP70) that in other lineages is addressed to the mitochondrial compartment. The phylogenetic reconstruction unambiguously located this HSP70 within a large set of mitochondrial sequences, itself a sister-group of alpha-purple bacteria. In addition, the T. vaginalis protein exhibits the GDAWV sequence signature, so far exclusively found in mitochondrial HSP70 and in proteobacterial dnaK. Thus mitochondrial endosymbiosis could have occurred earlier than previously assumed. The trichomonad double membrane-bounded organelles, the hydrogenosomes, could have evolved from mitochondria.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.