ArticleProceedings of the National Academy of Sciences of the United States of America1996
Complex formation between stage-specific oocyte factors and a Xenopus mRNA localization element.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Organizing the oocyte: RNA localization meets phase separation.Current topics in developmental biology · 2020Article
- High-throughput analysis reveals novel maternal germline RNAs crucial for primordial germ cell preservation and proper migration.Development (Cambridge, England) · 2017Article
- Hermes (Rbpms) is a Critical Component of RNP Complexes that Sequester Germline RNAs during Oogenesis.Journal of developmental biology · 2016Article
- Evidence for multiple, distinct ADAR-containing complexes in Xenopus laevis.RNA (New York, N.Y.) · 2015Article
- RNA localization in Xenopus oocytes uses a core group of trans-acting factors irrespective of destination.RNA (New York, N.Y.) · 2013Article
- Drosophila Syncrip binds the gurken mRNA localisation signal and regulates localised transcripts during axis specification.Biology open · 2012Article
- Isolation and identification of cytoskeleton-associated prolamine mRNA binding proteins from developing rice seeds.Planta · 2010Article
- Participation of Xenopus Elr-type proteins in vegetal mRNA localization during oogenesis.The Journal of biological chemistry · 2009Article
- Multiple kinesin motors coordinate cytoplasmic RNA transport on a subpopulation of microtubules in Xenopus oocytes.Developmental cell · 2008Article
- The RNA-binding protein XSeb4R: a positive regulator of VegT mRNA stability and translation that is required for germ layer formation in Xenopus.Genes & development · 2008Article
- PTB/hnRNP I is required for RNP remodeling during RNA localization in Xenopus oocytes.Molecular and cellular biology · 2008Article
- VICKZ proteins mediate cell migration via their RNA binding activity.RNA (New York, N.Y.) · 2007Article
- Cis-acting determinants of asymmetric, cytoplasmic RNA transport.RNA (New York, N.Y.) · 2007Review
- The Xenopus ELAV protein ElrB represses Vg1 mRNA translation during oogenesis.Molecular and cellular biology · 2005Article
- Localization of RNAs to the mitochondrial cloud in Xenopus oocytes through entrapment and association with endoplasmic reticulum.Molecular biology of the cell · 2004Article
- Nuclear RNP complex assembly initiates cytoplasmic RNA localization.The Journal of cell biology · 2004Article
- The KH domains of Xenopus Vg1RBP mediate RNA binding and self-association.RNA (New York, N.Y.) · 2002Article
- A 250-nucleotide UA-rich element in the 3' untranslated region of Xenopus laevis Vg1 mRNA represses translation both in vivo and in vitro.RNA (New York, N.Y.) · 2001Article
- A proline-rich protein binds to the localization element of Xenopus Vg1 mRNA and to ligands involved in actin polymerization.The EMBO journal · 2001Article
- A human sequence homologue of Staufen is an RNA-binding protein that is associated with polysomes and localizes to the rough endoplasmic reticulum.Molecular and cellular biology · 1999Article
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1 author.
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Abstract
It is a long-standing proposal that localization of maternal factors in eggs can provide the basis for pattern formation in the early embryo. The localized information can be stored as RNA, one example being Vg1 RNA, which is localized exclusively to the vegetal hemisphere of Xenopus oocytes and eggs. Localization of Vg1 mRNA is directed by a 340-nt sequence element contained within its 3' untranslated region. To understand the mechanism of localization, I have tested whether factors from the oocyte interact specifically with the RNA localization sequence. Results presented here show that a set of oocyte proteins form complexes with the localization element both in vitro and in vivo. These proteins are specifically enriched in the stages of oogenesis during which localization occurs and recognize sub-elements of the RNA localization element that are essential for localization in vivo. These data suggest that formation of a localization-specific RNA-protein complex may be the first step in directing Vg1 mRNA to its subcellular destination.
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