ArticleThe Journal of clinical investigation1996
Naturally processed T cell epitopes from human glutamic acid decarboxylase identified using mice transgenic for the type 1 diabetes-associated human MHC class II allele, DRB1*0401.
Article in The Journal of clinical investigation, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed, 137 citations in OpenAlex.
- Article
- Challenges and opportunities in analyzing and modeling peptide presentation by HLA-II proteins.Frontiers in immunology · 2023Article
- Preclinical Models to Evaluate the Human Response to Autoantigen and Antigen-Specific Immunotherapy in Human Type 1 Diabetes.Frontiers in endocrinology · 2022Review
- The induction of autoimmune hepatitis in the human leucocyte antigen-DR4 non-obese diabetic mice autoimmune hepatitis mouse model.Clinical and experimental immunology · 2016Article
- Aberrant Accumulation of the Diabetes Autoantigen GAD65 in Golgi Membranes in Conditions of ER Stress and Autoimmunity.Diabetes · 2016Article
- T cell epitopes and post-translationally modified epitopes in type 1 diabetes.Current diabetes reports · 2015Review
- Macronutrient deprivation modulates antigen trafficking and immune recognition through HSC70 accessibility.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Recognition of posttranslationally modified GAD65 epitopes in subjects with type 1 diabetes.Diabetes · 2014Article
- A humanized mouse model of autoimmune insulitis.Diabetes · 2014Article
- Immune therapy in type 1 diabetes mellitus.Nature reviews. Endocrinology · 2013Review
- Application of IgG-derived natural Treg epitopes (IgG Tregitopes) to antigen-specific tolerance induction in a murine model of type 1 diabetes.Journal of diabetes research · 2013Article
- Differences in self-peptide binding between T1D-related susceptible and protective DR4 subtypes.Journal of autoimmunity · 2011Article
- T cell recognition of autoantigens in human type 1 diabetes: clinical perspectives.Clinical & developmental immunology · 2011Review
- LAMP-2-deficient human B cells exhibit altered MHC class II presentation of exogenous antigens.Immunology · 2010Article
- Peptide-MHC cellular microarray with innovative data analysis system for simultaneously detecting multiple CD4 T-cell responses.PloS one · 2010Article
- HSP90alpha and HSP90beta isoforms selectively modulate MHC class II antigen presentation in B cells.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- Regulatory T cell-associated activity in photopheresis-induced immune tolerance in recent onset type 1 diabetes children.Clinical and experimental immunology · 2008Article
- Article
- Autoreactive human T-cell receptor initiates insulitis and impaired glucose tolerance in HLA DR4 transgenic mice.Journal of autoimmunity · 2008Article
- Antigen presentation of detergent-free glutamate decarboxylase (GAD65) is affected by human serum albumin as carrier protein.Journal of immunological methods · 2008Article
Corrections and comments
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Authors and funding
14 authors at 4 institutions in 3 countries.
Funding
Abstract
The identification of class II binding peptide epitopes from autoimmune disease-related antigens is an essential step in the development of antigen-specific immune modulation therapy. In the case of type 1 diabetes, T cell and B cell reactivity to the autoantigen glutamic acid decarboxylase 65 (GAD65) is associated with disease development in humans and in nonobese diabetic (NOD) mice. In this study, we identify two DRB1*0401-restricted T cell epitopes from human GAD65, 274-286, and 115-127. Both peptides are immunogenic in transgenic mice expressing functional DRB1*0401 MHC class II molecules but not in nontransgenic littermates. Processing of GAD65 by antigen presenting cells (APC) resulted in the formation of DRB1*0401 complexes loaded with either the 274-286 or 115-127 epitopes, suggesting that these naturally derived epitopes may be displayed on APC recruited into pancreatic islets. The presentation of these two T cell epitopes in the islets of DRB1*0401 individuals who are at risk for type 1 diabetes may allow for antigen-specific recruitment of regulatory cells to the islets following peptide immunization.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.