ArticleAnatomy and embryology1996
Development and ageing of the articular cartilage of the rabbit knee joint: distribution of the fibrillar collagens.
Article in Anatomy and embryology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 88 citations in OpenAlex.
- Age-dependent development and microarchitecture of the osteochondral unit of the humeral head in harbour porpoises (Phocoena phocoena).Scientific reports · 2026Article
- Local shear properties of rabbit articular cartilage capture surface region mechanics of human, equine, and bovine tissue.Journal of biomechanics · 2025Article
- Maturation of the Meniscal Collagen Structure Revealed by Polarization-Resolved and Directional Second Harmonic Generation Microscopy.Scientific reports · 2019Article
- Non-Invasive Monitoring of Functional State of Articular Cartilage Tissue with Label-Free Unsupervised Hyperspectral Imaging.Scientific reports · 2019Article
- Observation of sGAG content of human hip joint cartilage in different old age groups based on EPIC micro-CT.Connective tissue research · 2015Article
- Cell-based articular cartilage repair: the link between development and regeneration.Osteoarthritis and cartilage · 2015Review
- Differential gene expression of the intermediate and outer interzone layers of developing articular cartilage in murine embryos.Stem cells and development · 2014Article
- Immature articular cartilage and subchondral bone covered by menisci are potentially susceptive to mechanical load.BMC musculoskeletal disorders · 2014Article
- Article
- Ultrasonic reflection coefficient and surface roughness index of OA articular cartilage: relation to pathological assessment.BMC musculoskeletal disorders · 2012Article
- Epiphyseal Chondroprogenitors Provide a Stable Cell Source for Cartilage Cell Therapy.Cell medicine · 2012Article
- Cartilage biology, pathology, and repair.Cellular and molecular life sciences : CMLS · 2010Review
- Postnatal development of depth-dependent collagen density in ovine articular cartilage.BMC developmental biology · 2010Article
- Postnatal development of collagen structure in ovine articular cartilage.BMC developmental biology · 2010Article
- Transcriptional profiling and biochemical analysis of mechanically induced cartilaginous tissues in a rat model.Arthritis and rheumatism · 2010Article
- Differential gene expression associated with postnatal equine articular cartilage maturation.BMC musculoskeletal disorders · 2008Article
- Matrix development in self-assembly of articular cartilage.PloS one · 2008Article
- A distinct cohort of progenitor cells participates in synovial joint and articular cartilage formation during mouse limb skeletogenesis.Developmental biology · 2008Article
- Lineage tracing using matrilin-1 gene expression reveals that articular chondrocytes exist as the joint interzone forms.Developmental biology · 2007Article
- The hip joint: the fibrillar collagens associated with development and ageing in the rabbit.Journal of anatomy · 2001Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The development of the articular cartilage of the rabbit knee joint from the 17-day fetus to the 2-year adult rabbit has been examined. At 17 days, the developing femur and tibia are separated by the interzone. Cavitation occurs around 25 days; the cells of the intermediate layer flatten and move onto those of the chondogenous layers to create the articular surfaces. After birth, growth of the cartilage is mainly the result of matrix production. Ossification of the epiphyses is complete by 6 weeks postpartum. Horizontal zones can be distinguished in the articular cartilage; the superficial cells are aligned parallel to the surface, but in the deep layers the cells are in columns. The tidemark is first seen at 12-14 weeks. The matrix of the interzone in the 17-day fetus contains types I, III and V collagens, but no type II. After cavitation at 25 days, the surface layer of the articular cartilage still contains type I, but no type II collagen. From 6 weeks postnatal onwards, type II collagen is present throughout the cartilage and type I disappears. Type III collagen is initially in the inter-territorial matrix, but later it is mainly pericellular. Type V collagen is pericellular both in the chondrogenous layers and later in the articular cartilage, but is not present in the epiphyseal cartilage below. From 6 weeks onwards, types III and V collagens create a capsule around all the chondrocytes above the tidemark. The relationship of types V and XI collagens is discussed. It is concluded that the articular chondrocytes form a unique subset of cells from the earliest stages of joint formation in the fetal rabbit.
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