ArticleAnatomy and embryology1996
Onset of elastogenesis and downregulation of smooth muscle actin as distinguishing phenomena in artery differentiation in the chick embryo.
Article in Anatomy and embryology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 63 citations in OpenAlex.
- 3D vascular quantitation with application to computational modeling: a pre-clinical light sheet microscopy, high resolution ultrasound, nano-computed tomography comparison study.bioRxiv : the preprint server for biology · 2026Article
- Endothelial-derived angiocrine factors as instructors of embryonic development.Frontiers in cell and developmental biology · 2023Review
- The Development of the Ascending Aortic Wall in Tricuspid and Bicuspid Aortic Valve: A Process from Maturation to Degeneration.Journal of clinical medicine · 2020Article
- Heterogeneous Cellular Contributions to Elastic Laminae Formation in Arterial Wall Development.Circulation research · 2019Article
- Systematic Analysis of the Smooth Muscle Wall Phenotype of the Pharyngeal Arch Arteries During Their Reorganization into the Great Vessels and Its Association with Hemodynamics.Anatomical record (Hoboken, N.J. : 2007) · 2019Article
- Article
- Elastin in lung development and disease pathogenesis.Matrix biology : journal of the International Society for Matrix Biology · 2018Review
- An update on clonality: what smooth muscle cell type makes up the atherosclerotic plaque?F1000Research · 2018Review
- Growth and hemodynamics after early embryonic aortic arch occlusion.Biomechanics and modeling in mechanobiology · 2015Article
- Article
- Vascular extracellular matrix and arterial mechanics.Physiological reviews · 2009Review
- Developmental changes in the effects of prostaglandin E2 in the chicken ductus arteriosus.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2009Article
- Transcriptional regulation during development of the ductus arteriosus.Circulation research · 2008Article
- Maturation of the contractile response of the Emu ductus arteriosus.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2008Article
- Inhibition of cyclooxygenase isoforms in late- but not midgestation decreases contractility of the ductus arteriosus and prevents postnatal closure in mice.American journal of physiology. Regulatory, integrative and comparative physiology · 2006Article
- Developmental adaptation of the mouse cardiovascular system to elastin haploinsufficiency.The Journal of clinical investigation · 2003Article
- Transitions in cell organization and in expression of contractile and extracellular matrix proteins during development of chicken aortic smooth muscle: evidence for a complex spatial and temporal differentiation program.Anatomy and embryology · 1998Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During development, the arterial system is grossly divided into elastic and muscular vessel types. Apart from local environmental factors, it has been suggested that vascular smooth muscle cell origin (mesoderm or neural crest) is involved in this, as yet poorly understood, arterial differentiation. We describe differentiation of the thoracic arterial system in the chick embryo, using immunohistochemical techniques staining for muscle-specific actin, vinculin and desmin and histological staining to visualise elastin. The initial developmental stages of the vessel wall in all arteries appeared to be highly similar, with all arteries showing peri-endothelial actin and vinculin staining. Major alterations did not occur until the start of elastogenesis, which coincided with complete loss of actin staining from the proximal part of the great arteries. Later in development, however, actin was re-expressed in a subpopulation of medial cells, which also expressed vinculin and desmin. Concomitantly another, nonmuscular, cell type became evident in the great arteries. Transient loss of actin expression and segregation of very distinct cell populations occurred only in vessels prone to elastic development and known to receive a neural crest contribution. In contrast, arteries that developed a muscular phenotype never lost the initially acquired peri-endothelial actin expression. We also show a significant difference in the organisation of elastic fibres between elastic vessels that contain neural crest derivatives and those that do not. The ductus arteriosus still presents as an enigma in the sense that it is the only part of the pharyngeal arch complex that develops a muscular phenotype.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.