ArticleBritish journal of cancer1996
beta-1 Integrins mediate tumour cell adhesion to quiescent endothelial cells in vitro.
Article in British journal of cancer, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 24 citations in OpenAlex.
- Review
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- miR-720 is a downstream target of an ADAM8-induced ERK signaling cascade that promotes the migratory and invasive phenotype of triple-negative breast cancer cells.Breast cancer research : BCR · 2016Article
- Endothelial-mesenchymal transition of brain endothelial cells: possible role during metastatic extravasation.PloS one · 2015Article
- ADAM8 expression in invasive breast cancer promotes tumor dissemination and metastasis.EMBO molecular medicine · 2014Article
- αB-crystallin: a novel regulator of breast cancer metastasis to the brain.Clinical cancer research : an official journal of the American Association for Cancer Research · 2014Article
- Role of the protein tyrosine kinase Syk in regulating cell-cell adhesion and motility in breast cancer cells.Molecular cancer research : MCR · 2009Article
- NK4, an HGF antagonist, prevents hematogenous pulmonary metastasis by inhibiting adhesion of CT26 cells to endothelial cells.Clinical & experimental metastasis · 2009Article
- Interactions of human prostatic epithelial cells with bone marrow endothelium: binding and invasion.British journal of cancer · 2001Article
- Endothelial cell intracellular Ca2+ concentration is increased upon breast tumor cell contact and mediates tumor cell transendothelial migration.Clinical & experimental metastasis · 1998Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metastatic spread of some solid tumours is thought to depend upon the adhesion of tumour cells to the vascular endothelium followed by extravasation into surrounding tissues. We investigated the role of beta 1 integrins in the adhesion of the breast adenocarcinoma cell line MDA-MB-231 and the melanoma cell line RPMI-7951 to quiescent human umbilical vein endothelial cells (HUVEC) in vitro. In the course of adhesion assays, tumour cells were observed to adhere to quiescent HUVEC monolayers, particularly at endothelial cell-cell junctions. Immunohistochemistry revealed concentration of beta 1 integrin expression at these sites. Adhesion was reduced by pretreatment of either tumour cells or HUVEC with antibodies against beta 1 integrins. Simultaneous treatment of HUVECs and tumour cells with these antibodies produced an additive blocking effect, consistent with a heterotypic adhesion mechanism. Our data suggest that tumour cell and endothelial beta 1 integrins may play a crucial role in the arrest and migration of tumour cells through the vascular endothelium in the absence of endothelial 'activation'.
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